2020
Syncytiotrophoblast extracellular microvesicle profiles in maternal circulation for noninvasive diagnosis of preeclampsia
Levine L, Habertheuer A, Ram C, Korutla L, Schwartz N, Hu RW, Reddy S, Freas A, Zielinski PD, Harmon J, Molugu SK, Parry S, Vallabhajosyula P. Syncytiotrophoblast extracellular microvesicle profiles in maternal circulation for noninvasive diagnosis of preeclampsia. Scientific Reports 2020, 10: 6398. PMID: 32286341, PMCID: PMC7156695, DOI: 10.1038/s41598-020-62193-7.Peer-Reviewed Original ResearchConceptsSyncytin-1Preeclampsia groupMaternal circulationExtracellular vesiclesCommon placental pathologyHigh expressionDiagnosis of preeclampsiaConditions of preeclampsiaBone alkaline phosphatasePotential physiologic roleTissue-specific biomarkersExtracellular microvesiclesPlasma extracellular vesiclesAlkaline phosphatasePreeclampsia subjectsNormal pregnancyPlacental pathologyCell extracellular vesiclesImproved biomarkersMaternal bloodPreeclampsiaPlacental syncytiotrophoblastMaternal plasmaPlacental alkaline phosphatasePhysiologic role
2017
Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia
Tong M, Cheng SB, Chen Q, DeSousa J, Stone PR, James JL, Chamley LW, Sharma S. Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia. Scientific Reports 2017, 7: 6694. PMID: 28751735, PMCID: PMC5532246, DOI: 10.1038/s41598-017-07017-x.Peer-Reviewed Original ResearchConceptsPreeclamptic placentasMaternal circulationNormotensive placentasPreeclampsia-like symptomsProduction of transthyretinPathogenesis of preeclampsiaNano-vesiclesPlacental extracellular vesiclesSerum levelsPreeclamptic seraMaternal organsPreeclampsiaPlacentaTotal transthyretinWestern blottingQRT-PCRExtracellular vesiclesSignificant proportionTransthyretin
2016
Inflammatory processes are specifically enhanced in endothelial cells by placental-derived TNF-α: Implications in preeclampsia (PE)
Shaw J, Tang Z, Schneider H, Saljé K, Hansson SR, Guller S. Inflammatory processes are specifically enhanced in endothelial cells by placental-derived TNF-α: Implications in preeclampsia (PE). Placenta 2016, 43: 1-8. PMID: 27324092, DOI: 10.1016/j.placenta.2016.04.015.Peer-Reviewed Original ResearchConceptsPro-inflammatory cytokine secretionMaternal perfusateCytokine secretionEndothelial dysfunctionActivation markersEndothelial cellsTNF-α blocking antibodyDual perfusion modelMaternal endothelial dysfunctionPro-inflammatory cytokinesMCP-1 secretionTNF-α actionEndothelial cell linePlacental pathophysiologyEndothelial activationIL-6IL-8Maternal endotheliumInflammatory processDual perfusionMaternal circulationBlocking antibodiesPreeclampsiaTNFPerfusion model
2014
Syncytiotrophoblast Vesicles Show Altered micro-RNA and Haemoglobin Content after Ex-vivo Perfusion of Placentas with Haemoglobin to Mimic Preeclampsia
Cronqvist T, Saljé K, Familari M, Guller S, Schneider H, Gardiner C, Sargent IL, Redman CW, Mörgelin M, Åkerström B, Gram M, Hansson SR. Syncytiotrophoblast Vesicles Show Altered micro-RNA and Haemoglobin Content after Ex-vivo Perfusion of Placentas with Haemoglobin to Mimic Preeclampsia. PLOS ONE 2014, 9: e90020. PMID: 24587192, PMCID: PMC3937405, DOI: 10.1371/journal.pone.0090020.Peer-Reviewed Original ResearchConceptsPathology of preeclampsiaCell-free HbMiR-517bMiR-517aSyncytiotrophoblast vesiclesExtracellular free hemoglobinPerfusion of placentaEx vivo perfusion systemMicro-RNAsMaternal circulationMimic preeclampsiaMaternal sidePerfusion mediumFree hemoglobinHuman placentaPerfusion phaseSurface markersPlacentaMiR-141Hemoglobin contentPerfusionPerfusion systemPreeclampsiaHemoglobinQuantitative PCR
2013
Stem cells and the reproductive system: Historical perspective and future directions
Duke CM, Taylor HS. Stem cells and the reproductive system: Historical perspective and future directions. Maturitas 2013, 76: 284-289. PMID: 24144960, DOI: 10.1016/j.maturitas.2013.08.012.Peer-Reviewed Original ResearchConceptsEndometrial-derived stem cellsStem cellsNumber of oocytesBone marrow stem cellsFuture therapeutic benefitMarrow stem cellsEndometrial regenerationParenchymal regenerationEndometrial tissueFertility preservationUterine disordersDerived stem cellsFetal stem cellsHuman ovaryMaternal circulationParkinson's diseaseTherapeutic benefitNovel treatmentsMultipotent stem cellsFetal cellsReproductive diseasesDiseaseDisease statesMature oocytesReproductive systemMammary-Specific Ablation of the Calcium-Sensing Receptor During Lactation Alters Maternal Calcium Metabolism, Milk Calcium Transport, and Neonatal Calcium Accrual
Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. Mammary-Specific Ablation of the Calcium-Sensing Receptor During Lactation Alters Maternal Calcium Metabolism, Milk Calcium Transport, and Neonatal Calcium Accrual. Endocrinology 2013, 154: 3031-3042. PMID: 23782944, PMCID: PMC3749485, DOI: 10.1210/en.2012-2195.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBiological TransportBone DevelopmentBone ResorptionCalciumCrosses, GeneticFemaleGene Expression RegulationLactationLactoglobulinsMammary Glands, AnimalMiceMice, KnockoutMice, TransgenicMilkParathyroid HormoneParathyroid Hormone-Related ProteinReceptors, Calcium-SensingRNA, MessengerConceptsRenal calcium excretionCalcium excretionCalcium metabolismBone resorptionCalcium transportMilk calciumMammary glandAccelerated bone resorptionMammary-specific ablationMaternal calcium metabolismDietary calcium intakeCalcium sensing receptorCalcium-sensing receptorSecretion of PTHrPSkeletal calcium storesMilk PTHrPCalcium intakePTH secretionPTHrP secretionMaternal boneBone turnoverBone metabolismOnset of lactationMaternal circulationSystemic calcium
2010
Stem cells and reproduction
Du H, Taylor HS. Stem cells and reproduction. Current Opinion In Obstetrics & Gynecology 2010, 22: 235-241. PMID: 20305558, PMCID: PMC3107846, DOI: 10.1097/gco.0b013e328338c152.Peer-Reviewed Original ResearchConceptsStem cellsCause of endometriosisBone marrow transplantBone marrow stem cellsMarrow stem cellsStem cell biologyEndometrial regenerationMarrow transplantUterine disordersFetal stem cellsOrthotopic transplantationOvarian cancerMaternal circulationLive birthsEnd organsOvarian tissueFetal cellsUnderlying causeClinical potentialCell biologyMature oocytesDynamic organCell transformationNovel evidenceWomen
1988
Pulsed Doppler flow-velocity waveforms before and after intrauterine intravascular transfusion for severe erythroblastosis fetalis
Copel J, Grannum P, Belanger K, Green J, Hobbins J. Pulsed Doppler flow-velocity waveforms before and after intrauterine intravascular transfusion for severe erythroblastosis fetalis. American Journal Of Obstetrics And Gynecology 1988, 158: 768-774. PMID: 2966585, DOI: 10.1016/0002-9378(88)90070-1.Peer-Reviewed Original ResearchConceptsLate transfusionDoppler flow velocity waveformsIntrauterine intravascular transfusionFlow velocity waveformsSevere erythroblastosis fetalisFirst transfusionIntrauterine transfusionSubsequent transfusionsErythroblastosis fetalisIntravascular transfusionIsoimmunized pregnanciesDoppler studiesMaternal circulationDoppler ultrasoundTransfusionNormal fetusesHematocrit changesLack of changeHematocritDoppler parametersFetusesRapid volumeHydropsPregnancyFetalis
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