2023
Improved Overall Survival Among Luspatercept Responders and Predictors of Response
Consagra A, Lanino L, Al Ali N, Aguirre L, Xie Z, Chan O, Andreossi G, Rigodanza L, Sanna A, Raddi M, Walker A, Kuykendall A, Lancet J, Padron E, Sallman D, Restuccia F, Perego A, Ubezio M, Fattizzo B, Riva M, Campagna A, Della Porta M, Santini V, Komrokji R. Improved Overall Survival Among Luspatercept Responders and Predictors of Response. Blood 2023, 142: 1871. DOI: 10.1182/blood-2023-186279.Peer-Reviewed Original ResearchMoffitt Cancer CenterIPSS-MMedian OSRBC-TDRBC-TIErythroid stimulating agentsHematologic responsePredictors of responseOverall survivalNon-respondersHgb increasesTransfusion burdenHypomethylating agentsRinged sideroblastsLR-MDSAdverse eventsFirst-in-class erythroid maturation agentAssociated with improved OSMedian duration of responseLow-risk myelodysplastic syndromesRed blood cell transfusionErythroid maturation agentLow TB groupMedian OS benefitRBC transfusion burden
2022
Analysis of Tumor Burden as a Biomarker for Patient Survival with Neuroendocrine Tumor Liver Metastases Undergoing Intra-Arterial Therapies: A Single-Center Retrospective Analysis
Miszczuk M, Chapiro J, Do Minh D, van Breugel JMM, Smolka S, Rexha I, Tegel B, Lin M, Savic LJ, Hong K, Georgiades C, Nezami N. Analysis of Tumor Burden as a Biomarker for Patient Survival with Neuroendocrine Tumor Liver Metastases Undergoing Intra-Arterial Therapies: A Single-Center Retrospective Analysis. CardioVascular And Interventional Radiology 2022, 45: 1494-1502. PMID: 35941241, PMCID: PMC9587516, DOI: 10.1007/s00270-022-03209-9.Peer-Reviewed Original ResearchConceptsNeuroendocrine tumor liver metastasesMedian overall survivalIntra-arterial therapyLow tumor burdenTumor burdenOverall survivalLiver metastasesPrognostic factorsTumor diameterTB groupLonger median overall survivalRetrospective single-center analysisSingle-center retrospective analysisHigh TB groupLow TB groupRespective hazard ratiosHigh tumor burdenSingle-center analysisIndependent prognostic factorStrong prognostic factorDrug-eluting beadsLargest liver lesionPrediction of survivalHazard ratioPatient survival
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