2018
Nonalcoholic fatty liver disease impairs expression of the type II inositol 1,4,5‐trisphosphate receptor
Khamphaya T, Chukijrungroat N, Saengsirisuwan V, Mitchell‐Richards K, Robert ME, Mennone A, Ananthanarayanan M, Nathanson MH, Weerachayaphorn J. Nonalcoholic fatty liver disease impairs expression of the type II inositol 1,4,5‐trisphosphate receptor. Hepatology 2018, 67: 560-574. PMID: 29023819, PMCID: PMC5893412, DOI: 10.1002/hep.29588.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseImpaired liver regenerationNonalcoholic steatohepatitisLiver regenerationHuh7 cellsLiver diseaseEffect of NAFLDPrevalent liver diseaseFatty liver diseaseC-JunHigh-fructose dietLiver biopsy specimensCell proliferationCalcium signalingHepG2 cellsLiver of ratsCell nuclear antigenCalcium release channelSimple steatosisLiver biopsyFatty liverTrisphosphate receptorBiopsy specimensRat modelType II inositol
2011
Type 2 inositol 1,4,5‐trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes
Kruglov EA, Gautam S, Guerra MT, Nathanson MH. Type 2 inositol 1,4,5‐trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes. Hepatology 2011, 54: 1790-1799. PMID: 21748767, PMCID: PMC3205211, DOI: 10.1002/hep.24548.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsATP Binding Cassette Transporter, Subfamily B, Member 11ATP-Binding Cassette TransportersBile Acids and SaltsBile CanaliculiCalciumCalcium SignalingCell Culture TechniquesCells, CulturedCholestasisCollagenDisease Models, AnimalHepatocytesInositol 1,4,5-Trisphosphate ReceptorsLipopolysaccharidesMaleProtein Processing, Post-TranslationalRatsRats, Sprague-DawleyConceptsBile salt secretionBSEP activityTrisphosphate receptorBile salt export pumpType II inositolSalt secretionPosttranslational regulationCell systemType 2 inositolCanalicular membraneCholesterol depletionIntrahepatic cholestasisConfocal immunofluorescenceFunctional polarityIntracellular calciumIsolated cell systemRat hepatocytesAnimal modelsSandwich cultureCollagen sandwich culturesPharmacologic inhibitionShort-term regulationCell membraneExport pumpSecretion
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