Heterozygous mutations in factor H aggravate pathological damage in a stable IgA deposition model induced by Lactobacillus casei cell wall extract
Li J, Dong Y, Chen F, Yang H, Chen P, Li H, Shi S, Zhou X, Zhu L, Zhang Y, Liu L, Xie X, Yu F, Jin J, Lv J, Zhang H. Heterozygous mutations in factor H aggravate pathological damage in a stable IgA deposition model induced by Lactobacillus casei cell wall extract. Frontiers In Immunology 2024, 15: 1368322. PMID: 38558821, PMCID: PMC10978756, DOI: 10.3389/fimmu.2024.1368322.Peer-Reviewed Original ResearchCell wall extractsLactobacillus casei cell wall extractBiomarkers of kidney dysfunctionComplement activationFactor H mutationSeverity of glomerular lesionsPositive rate of IgAMild kidney damageDecline of kidney functionPathogenesis of IgA nephropathyProduction of IgA.Wall extractsGlomerular IgA depositionPathogenesis of IgANWild type controlsComplement overactivationElevated IgAElevated biomarkersHeterozygous mutationsC57BL/6 miceIgA-IgGKidney dysfunctionAlternative pathwayComplement inhibitorsIgA nephropathy
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