2025
Sculpting excitable membranes: voltage-gated ion channel delivery and distribution
Tyagi S, Higerd-Rusli G, Akin E, Waxman S, Dib-Hajj S. Sculpting excitable membranes: voltage-gated ion channel delivery and distribution. Nature Reviews Neuroscience 2025, 26: 313-332. PMID: 40175736, DOI: 10.1038/s41583-025-00917-2.Peer-Reviewed Original ResearchConceptsNeuronal compartmentsPeripheral nervous system neuronsIon channel localizationNervous system neuronsMembrane ion channelsIon channel traffickingChronic painNeuronal excitabilityPotential therapeutic targetChannel traffickingIon channel distributionSystem neuronsChannel localizationNeuronal activityTherapeutic targetIon channelsTarget membrane insertionPost-translational modificationsDistal neuronal compartmentsDisease statesNeuronal homeostasisVesicular sortingDiseaseSpatiotemporal regulationChannel delivery
1987
Molecular neurobiology of the myelinated nerve fiber: ion-channel distributions and their implications for demyelinating diseases.
Waxman S. Molecular neurobiology of the myelinated nerve fiber: ion-channel distributions and their implications for demyelinating diseases. Proceedings Of The Association For Research In Nervous And Mental Disease 1987, 65: 7-37. PMID: 2455313.Peer-Reviewed Original Research
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