2010
Skin Exposure and Asthma
Redlich CA. Skin Exposure and Asthma. Annals Of The American Thoracic Society 2010, 7: 134-137. PMID: 20427586, PMCID: PMC3266020, DOI: 10.1513/pats.201002-025rm.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSkin exposureSite of sensitizationSubsequent inhalation challengeAsthma risk factorsImpair skin barrier functionFilaggrin gene mutationsSkin barrier functionAllergen entryAsthmatic responseInhalation challengeSubsequent asthmaAsthma developmentRisk factorsRespiratory tractHuman skin exposureAsthma riskSkin traumaAnimal studiesEpidemiology studiesBarrier functionEnvironmental exposuresGene mutationsProtein allergensSensitizationExposure assessment
2008
Lung/skin connections in occupational lung disease
Redlich C, Herrick C. Lung/skin connections in occupational lung disease. Current Opinion In Internal Medicine 2008, 7: 215-219. DOI: 10.1097/mci.0b013e328303e3cb.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsOccupational lung diseaseLung diseaseChronic beryllium diseaseSkin exposureIsocyanate asthmaBeryllium diseaseSite of sensitizationSubsequent inhalation challengeEnvironmental lung diseaseLimited clinical studiesImpair skin barrier functionSkin barrier functionAsthmatic responseInhalation challengeRespiratory tractHuman skin exposureClinical studiesInhalation exposureRecent studiesAnimal studiesAirborne exposureDiseaseBarrier functionPersonal protective clothingProtein allergensHuman innate immune responses to hexamethylene diisocyanate (HDI) and HDI–albumin conjugates
Wisnewski AV, Liu Q, Liu J, Redlich CA. Human innate immune responses to hexamethylene diisocyanate (HDI) and HDI–albumin conjugates. Clinical & Experimental Allergy 2008, 38: 957-967. PMID: 18498542, PMCID: PMC3131007, DOI: 10.1111/j.1365-2222.2008.02982.x.Peer-Reviewed Original ResearchMeSH KeywordsAdipokinesAdministration, InhalationAlbuminsAntigens, CDBlotting, WesternCells, CulturedChemokine CCL2Chitinase-3-Like Protein 1ChitinasesCyanatesEnzyme-Linked Immunosorbent AssayGene ExpressionGlycoproteinsHumansImmunity, InnateIntramolecular OxidoreductasesIsocyanatesLectinsLeukocytes, MononuclearLysosomesMacrophage Migration-Inhibitory FactorsMicroscopy, FluorescenceOligonucleotide Array Sequence AnalysisPolymerase Chain ReactionPolymorphism, GeneticProteinsRNAConceptsPeripheral blood mononuclear cellsInnate immune responseImmune responsePercentage of PBMCHuman peripheral blood mononuclear cellsFlow cytometrySystemic innate immune responseExposure-dependent decreaseMonocyte/macrophage traffickingHuman innate immune responseProtein expressionSpecific inhalation challengeBlood mononuclear cellsAdaptive immune responsesLow-density lipoproteinPattern recognition receptorsInhalation challengeOccupational asthmaClinical spectrumControl antigenMononuclear cellsHDI exposureSerum concentrationsAdaptive immunityGene/protein expressionLung/skin connections in occupational lung disease
Redlich CA, Herrick CA. Lung/skin connections in occupational lung disease. Current Opinion In Allergy And Clinical Immunology 2008, 8: 115-119. PMID: 18317018, DOI: 10.1097/aci.0b013e3282f85a31.Peer-Reviewed Original ResearchConceptsOccupational lung diseaseLung diseaseChronic beryllium diseaseSkin exposureIsocyanate asthmaBeryllium diseaseSite of sensitizationSubsequent inhalation challengeEnvironmental lung diseaseLimited clinical studiesImpair skin barrier functionSkin barrier functionAsthmatic responseInhalation challengeRespiratory tractHuman skin exposureClinical studiesInhalation exposureRecent studiesAnimal studiesAirborne exposureDiseaseBarrier functionPersonal protective clothingProtein allergens
2007
Diisocyanate conjugate and immunoassay characteristics influence detection of specific antibodies in HDI‐exposed workers
Campo P, Wisnewski AV, Lummus Z, Cartier A, Malo J, Boulet LP, Bernstein DI. Diisocyanate conjugate and immunoassay characteristics influence detection of specific antibodies in HDI‐exposed workers. Clinical & Experimental Allergy 2007, 37: 1095-1102. PMID: 17581205, DOI: 10.1111/j.1365-2222.2007.02745.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir Pollutants, OccupationalAsthmaBronchial Provocation TestsCyanatesEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoassayImmunoglobulin EImmunoglobulin GInhalation ExposureIsocyanatesMaleMiddle AgedMolecular StructureObserver VariationOccupational DiseasesPredictive Value of TestsQuality ControlQuebecRadioallergosorbent TestReagent Kits, DiagnosticReproducibility of ResultsSensitivity and SpecificitySerum AlbuminSkin TestsConceptsSpecific inhalation challengeDiisocyanate asthmaSpecific IgEHuman serum albumin conjugatesSpecific antibodiesSpecific IgG antibodiesInhalation challengeAsthmatic reactionSpecific IgGHDI exposureIgG antibodiesTest antigenPredictive valueSerum albumin conjugatesAntigen immunoassayIgEProtein antigensIgG immunoassayShop workersInter-laboratory variabilityAlbumin conjugatesAntibodiesAsthmaRASTIgGDevelopments in laboratory diagnostics for isocyanate asthma
Wisnewski AV. Developments in laboratory diagnostics for isocyanate asthma. Current Opinion In Allergy And Clinical Immunology 2007, 7: 138-145. PMID: 17351466, PMCID: PMC3131002, DOI: 10.1097/aci.0b013e3280895d22.Peer-Reviewed Original ResearchConceptsIsocyanate asthmaSpecific inhalation challengeCause of asthmaEnzyme-linked immunosorbentBiomarkers of exposureGold standard testInhalation challengeOccupational asthmaAsthma pathogenesisRisk factorsSpecialized centersAsthmaWorkplace exposuresAsthma diagnosticsEfficient laboratory testsHuman IgELaboratory testsClinical diagnosisContemporary laboratory testsLaboratory diagnosticsSubset of workersIgEDisease developmentExposureCauseCost‐Effectiveness of Various Diagnostic Approaches for Occupational Asthma
Kennedy WA, Girard F, Chaboillez S, Cartier A, Côté J, Hargreave F, Labrecque M, Malo JL, Tarlo SM, Redlich CA, Lemière C. Cost‐Effectiveness of Various Diagnostic Approaches for Occupational Asthma. Canadian Respiratory Journal 2007, 14: 276-280. PMID: 17703242, PMCID: PMC2676393, DOI: 10.1155/2007/206519.Peer-Reviewed Original ResearchConceptsSpecific inhalation challengeOccupational asthmaSputum testingProbabilistic sensitivity analysesPEF monitoringDiagnosis of OASputum cell countsProportion of eosinophilsExpiratory flow monitoringAdditional correct diagnosisBase-case analysisInhalation challengeClinical outcomesOA patientsTreeAge ProClinical dataSerial measurementsCorrect diagnosisPatientsCanadian hospitalsCell countDiagnostic approachGold standardDiagnosisCost-effective alternative
2006
Skin Exposure to Isocyanates: Reasons for Concern
Bello D, Herrick CA, Smith TJ, Woskie SR, Streicher RP, Cullen MR, Liu Y, Redlich CA. Skin Exposure to Isocyanates: Reasons for Concern. Environmental Health Perspectives 2006, 115: 328-335. PMID: 17431479, PMCID: PMC1849909, DOI: 10.1289/ehp.9557.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSkin exposureIsocyanate asthmaSuch exposureAsthma-like responsesSubsequent inhalation challengeOccupational SafetyPersonal protective equipmentInhalation challengeOccupational asthmaSystemic sensitizationAsthmaInhalation exposureHealth AdministrationComputerized searchRespiratory exposureRelevant articlesProtective equipmentHuman literatureSkin absorptionSensitizationGoogle databasesNational InstituteLines of evidencePotential roleSufficient evidence
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