2022
Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies
Martelli F, Hernandes N, Zuo Z, Wang J, Wong C, Karagas N, Roessner U, Rupasinghe T, Robin C, Venkatachalam K, Perry T, Batterham P, Bellen H. Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies. ELife 2022, 11: e73812. PMID: 35191376, PMCID: PMC8863376, DOI: 10.7554/elife.73812.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesBeneficial insectsBeneficial insect speciesElevated reactive oxygen speciesInsect speciesInsect pestsMitochondrial stressMitochondrial defectsAdult virgin femalesLysosomal defectsGlobal declineAntioxidant N-acetylcysteine amidePopulation sizeSpinosad toxicityMode of actionLipid storageMetabolic tissuesVirgin femalesInsecticide applicationsLysosomal dysfunctionInsectsSevere neurodegenerationSynthetic insecticidesOxygen speciesAlpha 6
2021
An ammonium transporter is a non-canonical olfactory receptor for ammonia
Vulpe A, Kim HS, Ballou S, Wu ST, Grabe V, Nava Gonzales C, Liang T, Sachse S, Jeanne JM, Su CY, Menuz K. An ammonium transporter is a non-canonical olfactory receptor for ammonia. Current Biology 2021, 31: 3382-3390.e7. PMID: 34111404, PMCID: PMC8355169, DOI: 10.1016/j.cub.2021.05.025.Peer-Reviewed Original ResearchConceptsOlfactory receptorsGenetic model organism Drosophila melanogasterModel organism Drosophila melanogasterAmmonium transporter familyCanonical olfactory receptorsIon channel functionAmmonium transportersInsect speciesDrosophila melanogasterMost insectsMutant fliesFirst transporterParticular olfactory receptorTransporter familyAgricultural pestsHematophagous insectsEctopic expressionDrosophilaInsectsChannel functionWidespread importanceAmmonia sensitivitySpeciesTransportersReceptorsSight of parasitoid wasps accelerates sexual behavior and upregulates a micropeptide gene in Drosophila
Ebrahim SAM, Talross GJS, Carlson JR. Sight of parasitoid wasps accelerates sexual behavior and upregulates a micropeptide gene in Drosophila. Nature Communications 2021, 12: 2453. PMID: 33907186, PMCID: PMC8079388, DOI: 10.1038/s41467-021-22712-0.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsAnimals, Genetically Modifiedbeta-Carotene 15,15'-MonooxygenaseCarnivoryDrosophilaDrosophila melanogasterDrosophila ProteinsDrosophila simulansFemaleFertilityGene Expression RegulationMaleNeuronsPattern Recognition, VisualReceptors, Ionotropic GlutamateReceptors, OdorantSexual Behavior, AnimalWaspsConceptsWasp speciesParasitoid waspsParasitoid wasp speciesInsect speciesAdult DrosophilaInsect worldMating behaviorMutational analysisGene expressionFemale fliesWaspsGenesDrosophilaSpeciesFliesDramatic upregulationDefensive responsesWidespread deathVisual circuitsInsectsMicropeptidesBehavioral responsesNervous systemHundreds of thousandsUnexpected responses
2015
Wigglesworthia
Aksoy S. Wigglesworthia. 2015, 1-6. DOI: 10.1002/9781118960608.gbm01172.Peer-Reviewed Original ResearchTypical Gram-negative cell wallGram-negative cell wallHost insect speciesInsect host speciesMilk gland secretionsInner membrane structureObligate intracellular organismsPrimary endosymbiontDifferentiated epithelial cellsInsect speciesIntrauterine larvaeS-symbiontsWigglesworthiaHost speciesLack flagellaAncient associationBiosynthetic pathwayAdult fliesMidgut tissueSpecies displayCell wallBinary fissionEndosymbiontsAposymbiotic hostsAnterior midgut
2012
Molecular characterization of DSC1 orthologs in invertebrate species
Cui YJ, Yu LL, Xu HJ, Dong K, Zhang CX. Molecular characterization of DSC1 orthologs in invertebrate species. Insect Biochemistry And Molecular Biology 2012, 42: 353-359. PMID: 22321571, DOI: 10.1016/j.ibmb.2012.01.005.Peer-Reviewed Original ResearchConceptsInvertebrate speciesVoltage-gated sodiumVoltage-gated cation channelsFull-length cDNACation channelsEvolutionary relationshipsInsect speciesArachnid speciesVertebrate speciesPhylogenetic analysisGenome sequenceOrthologsPhylum MolluscaBrown planthopperVarroa destructorPest controlMolecular characterizationSafe insecticidesClassical calcium channelsCalcium channelsSpeciesUnique familyNovel familyMotifDSC1
2007
Symbiosis-Based Technological Advances to Improve Tsetse Glossina spp. SIT Application
Aksoy S, Weiss B. Symbiosis-Based Technological Advances to Improve Tsetse Glossina spp. SIT Application. 2007, 137-148. DOI: 10.1007/978-1-4020-6059-5_12.Peer-Reviewed Original ResearchSterile insect techniqueCytoplasmic incompatibilityField populationsWolbachia infectionGene productsTsetse fliesGerm-line transformationComplete genome sequencePresence of WolbachiaGene expression experimentsPest control toolForeign gene productsParasitic African trypanosomesGlossina sppMidgut symbiontsArea-wide basisFly developmentInsect speciesReproductive incompatibilitySIT applicationMale sterilityUninfected insectsGenome sequenceMating incompatibilityExpression experiments
2000
Wolbachia neither induces nor suppresses transcripts encoding antimicrobial peptides
Bourtzis K, Pettigrew M, O’Neill S. Wolbachia neither induces nor suppresses transcripts encoding antimicrobial peptides. Insect Molecular Biology 2000, 9: 635-639. PMID: 11122472, DOI: 10.1046/j.1365-2583.2000.00224.x.Peer-Reviewed Original ResearchConceptsInsect speciesCytoplasmic incompatibilityDifferent tissue tropismsSingle WolbachiaDefensin genesAntibacterial genesArthropod speciesAnopheles gambiaeWolbachiaExpression patternsMosquito speciesSpeciesGenesMosquito defensinUbiquitous parasiteHost immune systemImmune systemTissue tropismAntimicrobial peptidesTranscriptionAedes aegyptiAedes albopictusReproductive abnormalitiesDrosophilaParthenogenesis
1999
Concordant Evolution of a Symbiont with Its Host Insect Species: Molecular Phylogeny of Genus Glossina and Its Bacteriome-Associated Endosymbiont, Wigglesworthia glossinidia
Chen X, Li S, Aksoy S. Concordant Evolution of a Symbiont with Its Host Insect Species: Molecular Phylogeny of Genus Glossina and Its Bacteriome-Associated Endosymbiont, Wigglesworthia glossinidia. Journal Of Molecular Evolution 1999, 48: 49-58. PMID: 9873076, DOI: 10.1007/pl00006444.Peer-Reviewed Original ResearchConceptsHost insect speciesRDNA sequence analysisInsect speciesGroup speciesSequence analysisSister-group relationshipSpacer 2 (ITS2) regionParasitic African trypanosomesWigglesworthia glossinidiaMolecular phylogenyDifferentiated epithelial cellsGlossina austeniPrimary symbiontSecondary symbiontsSymbiotic associationDistinct lineagesRibosomal DNAGenus WolbachiaSymbiotic organismsTaxonomic placementΓ-subdivisionITS-2Third organismMidgut cellsAfrican trypanosomes
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