2021
Sensitive and Feasible Specimen Collection and Testing Strategies for Diagnosing Tuberculosis in Young Children
Song R, Click ES, McCarthy KD, Heilig CM, Mchembere W, Smith JP, Fajans M, Musau SK, Okeyo E, Okumu A, Orwa J, Gethi D, Odeny L, Lee SH, Perez-Velez CM, Wright CA, Cain KP. Sensitive and Feasible Specimen Collection and Testing Strategies for Diagnosing Tuberculosis in Young Children. JAMA Pediatrics 2021, 175: e206069. PMID: 33616611, PMCID: PMC7900937, DOI: 10.1001/jamapediatrics.2020.6069.Peer-Reviewed Original ResearchConceptsGastric aspiratesNPA samplesResource-limited settingsCurrent reference standardDiagnostic yieldTuberculosis diagnosisXpert MTB/RIFCross-sectional diagnostic studyReference standardNasopharyngeal aspirate samplesSymptoms of tuberculosisMycobacteria growth indicator tube (MGIT) cultureMTB/RIFIncremental diagnostic yieldPositive test resultsYoung childrenSpecimen typesInvasive specimenCervical lymphadenopathyMedian ageMycobacterium tuberculosis complexParenchymal abnormalitiesConsecutive seriesOutpatient settingAspirate samples
2011
Adherence to biopsy guidelines increases celiac disease diagnosis
Lebwohl B, Kapel RC, Neugut AI, Green PH, Genta RM. Adherence to biopsy guidelines increases celiac disease diagnosis. Gastrointestinal Endoscopy 2011, 74: 103-109. PMID: 21601201, PMCID: PMC3651876, DOI: 10.1016/j.gie.2011.03.1236.Peer-Reviewed Original ResearchConceptsDuodenal biopsiesCeliac diseaseClinical practiceDiagnosis rateRetrospective cohort studyProportion of biopsiesRate of adherenceDuodenal biopsy specimensMultivariate logistic regressionIncremental diagnostic yieldCeliac disease diagnosisSmall absolute increaseCohort studyGuideline publicationDegree of adherenceBiopsy specimensDiagnostic yieldRetrospective analysisNew diagnosisBiopsyPatientsLogistic regressionAbsolute increasePathology laboratoryStudy period
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