HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection
Guo Y, Li L, Xu T, Guo X, Wang C, Li Y, Yang Y, Yang D, Sun B, Zhao X, Shao G, Qi X. HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection. Journal Of Clinical Investigation 2020, 130: 6301-6316. PMID: 33104527, PMCID: PMC7685759, DOI: 10.1172/jci138234.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosis Regulatory ProteinsBacteriaBacterial InfectionsCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsCaspase 1DNA-Binding ProteinsHEK293 CellsHumansInflammasomesInterleukin-1betaMacrophagesMiceMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinTumor Suppressor ProteinsUbiquitin-Protein LigasesConceptsCaspase-1 activationBone marrow-derived macrophagesE3 ubiquitin ligase HUWE1Inflammasome activationUbiquitin ligase HUWE1K27-linked polyubiquitinationBacterial infectionsMechanisms of inflammasome activationBH3 domainASC speck formationHIN domainCaspase-1 maturationPromote host defenseIncreased bacterial burdenNACHT domain of NLRP3NACHT domainHUWE1Decreased caspase-1 activationAcinetobacter baumannii infectionsInflammasome assemblyInduce NLRP3Human cellsHost defenseSpeck formationAIM2 inflammasome activation
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