2025
Exploring mucosal immune development and function in utero
Strine M, Vahkal B, St Denis K, Konnikova L. Exploring mucosal immune development and function in utero. Trends In Immunology 2025 PMID: 40518358, DOI: 10.1016/j.it.2025.05.004.Peer-Reviewed Original ResearchReframing the paradigm- rethinking placental and fetal immunity
Konnikova L. Reframing the paradigm- rethinking placental and fetal immunity. Placenta 2025 PMID: 40425428, DOI: 10.1016/j.placenta.2025.05.011.Peer-Reviewed Original ResearchPreterm birthMemory T cellsFetal immunityPreterm laborT cellsImmune cellsImmune developmentImmune systemNeonatal immune cellsReducing preterm laborFetal immune systemFetal immune developmentWeeks of gestationFetal immune responseMaternal tolerancePlacental immunityFetal organsCord bloodImmune environmentInfant bloodNeonatal healthImmunological issuesNeonatal protectionPrevent complicationsImmune response
2023
Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies
Kennedy K, de Goffau M, Perez-Muñoz M, Arrieta M, Bäckhed F, Bork P, Braun T, Bushman F, Dore J, de Vos W, Earl A, Eisen J, Elovitz M, Ganal-Vonarburg S, Gänzle M, Garrett W, Hall L, Hornef M, Huttenhower C, Konnikova L, Lebeer S, Macpherson A, Massey R, McHardy A, Koren O, Lawley T, Ley R, O’Mahony L, O’Toole P, Pamer E, Parkhill J, Raes J, Rattei T, Salonen A, Segal E, Segata N, Shanahan F, Sloboda D, Smith G, Sokol H, Spector T, Surette M, Tannock G, Walker A, Yassour M, Walter J. Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies. Nature 2023, 613: 639-649. PMID: 36697862, PMCID: PMC11333990, DOI: 10.1038/s41586-022-05546-8.Peer-Reviewed Original ResearchConceptsMicrobial populationsHuman immune developmentMicrobial ecologyReproductive biologyMicrobial communitiesLow biomass environmentsMicrobial signalsMicrobial studiesDNA sequencingMicrobiome studiesDNA extractionMicrobial analysisClinical microbiologyMechanistic conceptsCautionary exampleImmune developmentRecent studiesHuman fetusesFetal tissuesMammalsGnotobiologyEcologyMicrobiologyFetal microbiomeBiology
2021
Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia
Whitehead TP, Wiemels JL, Zhou M, Kang AY, McCoy LS, Wang R, Fitch B, Petrick LM, Yano Y, Imani P, Rappaport SM, Dahl GV, Kogan SC, Ma X, Metayer C. Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia. Cancer Epidemiology Biomarkers & Prevention 2021, 30: 1526-1535. PMID: 34078642, PMCID: PMC8338848, DOI: 10.1158/1055-9965.epi-20-1704.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCytokine levelsLymphoblastic leukemiaChildhood acute lymphoblastic leukemiaAberrant immune reactionsPrenatal immune developmentRisk of childhoodInterquartile range incrementAltered cytokine levelsCalifornia Childhood Leukemia StudyChildhood Leukemia StudyBirth characteristicsNeonatal levelsPrenatal exposureImmunomodulatory cytokinesImmune developmentHigh hyperdiploidyImmune reactionsCytokinesGM-CSFBlood spotsLogistic regressionLeukemia StudyEndogenous metabolitesConfidence intervalsSignature of Enhanced Effector Function Defines Early Life Regulatory T Cells
Connors T, Bradley M, Verma S, Waldman E, Jang M, Grunstein E, Maurrasse S, Pethe K, Dogra P, Farber D. Signature of Enhanced Effector Function Defines Early Life Regulatory T Cells. The Journal Of Immunology 2021, 206: 98.27-98.27. DOI: 10.4049/jimmunol.206.supp.98.27.Peer-Reviewed Original ResearchRegulatory T cellsT cellsImmune responseEarly lifeGut-specific homingPrimary antigenic challengeIntestinal immune homeostasisConventional T cellsPotential effector mechanismsInflammatory immune responseEnhanced effector functionMulti-parameter flow cytometryAdult TregsImmunosuppressive mechanismsAntigenic challengeImmune homeostasisEffector mechanismsTregsImmune developmentEffector functionsSuppressive functionImmunological challengeHigh proliferative capacityCell cycleBulk RNA sequencingPattern of circulating SARS‐CoV‐2‐specific antibody‐secreting and memory B‐cell generation in patients with acute COVID‐19
Byazrova M, Yusubalieva G, Spiridonova A, Efimov G, Mazurov D, Baranov K, Baklaushev V, Filatov A. Pattern of circulating SARS‐CoV‐2‐specific antibody‐secreting and memory B‐cell generation in patients with acute COVID‐19. Clinical & Translational Immunology 2021, 10: e1245. PMID: 33552508, PMCID: PMC7848539, DOI: 10.1002/cti2.1245.Peer-Reviewed Original ResearchAntibody-secreting cellsAcute phase of COVID-19Bmem cellsAcute phaseImmunological memoryStimulation of purified B cellsMemory B cell generationPhase of COVID-19Longevity of immunological memoryB cell generationB cell memoryPeripheral blood samplesGeneration of plasmablastsHumoral immunity developmentDisease-specific antigensELISPOT analysisEfficacy of vaccinesELISPOT assayMemory BB cellsSpontaneous secretionAntibody-secretingPhenotype cellsImmune developmentCell-derived
2012
Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly
Kollmann TR, Levy O, Montgomery RR, Goriely S. Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly. Immunity 2012, 37: 771-783. PMID: 23159225, PMCID: PMC3538030, DOI: 10.1016/j.immuni.2012.10.014.Peer-Reviewed Original ResearchConceptsInnate immune functionEnd of lifeImmune functionReceptor-mediated immune responsesInnate cytokine responsesToll-like receptorsMonths of lifeInnate immune systemHost-environment interactionsClinical patternCytokine responsesExcessive inflammationImmune developmentParticular infectionImmune responseImmune systemRisk periodOlder adultsSimilar patternDevelopmental patternsResponseInflammationNewbornsInfantsInfection
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