2016
Age‐associated vascular inflammation promotes monocytosis during atherogenesis
Du W, Wong C, Song Y, Shen H, Mori D, Rotllan N, Price N, Dobrian AD, Meng H, Kleinstein SH, Fernandez‐Hernando C, Goldstein DR. Age‐associated vascular inflammation promotes monocytosis during atherogenesis. Aging Cell 2016, 15: 766-777. PMID: 27135421, PMCID: PMC4933655, DOI: 10.1111/acel.12488.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAortaAtherosclerosisBlood VesselsCell CountChemotaxisCulture Media, ConditionedDiet, High-FatDown-RegulationHematopoiesisHemodynamicsInflammationInflammation MediatorsInsulin ResistanceInterleukin-6LeukocytosisMacrophagesMaleMiceMice, Inbred C57BLMonocytesOligonucleotide Array Sequence AnalysisReceptors, LDLStromal CellsUp-RegulationConceptsHigh-fat dietVascular inflammationMacrophage accumulationAtherosclerotic aortaBone marrow transplant experimentsStromal factorsElevated blood pressureVascular smooth muscle cellsLow-fat dietSmooth muscle cellsBlood pressurePeripheral monocytosisProinflammatory stateInflammatory stateLDL levelsIL-6Insulin resistancePeripheral bloodEnhanced atherogenesisInflammatory responseMetabolic dysfunctionYoung aortasMurine modelProduction of osteopontinCCL-2
2006
Reduced expression of inducible gelatinase B/matrix metalloproteinase-9 in monocytes from patients with myelodysplastic syndrome: correlation of inducible levels with the percentage of cytogenetically marked cells and with marrow cellularity
Iwata M, Pillai M, Ramakrishnan A, Hackman R, Deeg H, Opdenakker G, Torok-Storb B. Reduced expression of inducible gelatinase B/matrix metalloproteinase-9 in monocytes from patients with myelodysplastic syndrome: correlation of inducible levels with the percentage of cytogenetically marked cells and with marrow cellularity. Blood 2006, 109: 85-92. PMID: 16954500, PMCID: PMC1785081, DOI: 10.1182/blood-2006-05-020289.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBone MarrowCells, CulturedChemokinesCulture Media, ConditionedCytokinesEnzyme InductionFemaleFibroblastsHumansIn Situ Hybridization, FluorescenceLipopolysaccharide ReceptorsMaleMatrix Metalloproteinase 9Middle AgedMonocytesMyelodysplastic SyndromesRecombinant ProteinsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerStromal CellsConceptsMMP-9Myelodysplastic syndromeMarrow cellularityMonocyte populationsMatrix metalloproteinasesGelatinase B/matrix metalloproteinase-9Stromal cellsMCP-1/CCL2IL-8/CXCL8SDF-1/CXCL12Matrix metalloproteinase-9MMP-9 expressionMarker-positive cellsInducible levelsMDS patientsIL-6Healthy donorsMetalloproteinase-9Marrow stromal cellsG-CSFPatientsGM-CSFMonocytesStromal factorsM-CSF
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply