2024
Leptin augments IL-13–induced airway eotaxins and submucosal eosinophilia in obesity-associated asthma
Ingram J, McQuade V, Weiss J, Womble J, Ihrie M, Zhao K, Francisco D, Theriot B, May K, Kim H, McCravy M, Sauler M, Lugogo N, Sunday M, Everitt J, Walker J, Tighe R, Kraft M, Que L. Leptin augments IL-13–induced airway eotaxins and submucosal eosinophilia in obesity-associated asthma. Journal Of Allergy And Clinical Immunology 2024, 155: 819-833.e10. PMID: 39581293, PMCID: PMC11875949, DOI: 10.1016/j.jaci.2024.10.039.Peer-Reviewed Original ResearchAirway tissue eosinophiliaBronchoalveolar lavage fluidEotaxin productionHuman airway fibroblastsT2 asthmaAirway fibroblastsIL-13Ra2Tissue eosinophiliaMouse model of chronic allergic airways diseaseEotaxin-1Interleukin-13 receptor alpha 2Chronic allergic airway diseaseNeutralizing antibodies in vitroObesity-associated asthmaLung tissue eosinophiliaConcentration of exhaled nitric oxideFractional concentration of exhaled nitric oxideAllergic airway diseaseEotaxin-1 levelsExhaled Nitric OxideBody mass indexAntibodies in vitroHouse dust mite allergen exposureCombined leptinIL13RA2 expression
2016
Uricase Inhibits Nitrogen Dioxide–Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism
Ather JL, Burgess EJ, Hoyt LR, Randall MJ, Mandal MK, Matthews DE, Boyson JE, Poynter ME. Uricase Inhibits Nitrogen Dioxide–Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism. The Journal Of Immunology 2016, 197: 1720-1732. PMID: 27465529, PMCID: PMC4992621, DOI: 10.4049/jimmunol.1600336.Peer-Reviewed Original ResearchConceptsAllergic airway diseaseAllergic sensitizationAirway diseaseUric acidDevelopment of OVAOVA-specific responsesAirways of miceUric acid levelsAdaptive immune responsesOVA-specific AbT cell proliferationPowerful inhibitory effectEnvironmental air pollutantsImmune deviationOVA challengeOVA uptakeDendritic cellsCytokine productionAdjuvant activityImmune responseRespiratory diseaseMouse modelUric acid formationInhibitory effectAcid levels
2013
The Endogenous Th17 Response in NO2-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer
Martin RA, Ather JL, Daggett R, Hoyt L, Alcorn JF, Suratt BT, Weiss DJ, Lundblad LK, Poynter ME. The Endogenous Th17 Response in NO2-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer. PLOS ONE 2013, 8: e74730. PMID: 24069338, PMCID: PMC3778003, DOI: 10.1371/journal.pone.0074730.Peer-Reviewed Original ResearchConceptsAllergic airway diseaseAirway hyperresponsivenessAirway diseaseAdoptive transferAntigen challengeCytokine productionNeutrophil recruitmentIL-1RDevelopment of AHRIL-1 receptor signalingLung cellsGlucocorticoid-resistant asthmaIL-17A neutralizationOTII T cellsAdaptive immune responsesDecreased neutrophil recruitmentAHR developmentClinical asthmaMixed Th2Antigen restimulationSevere asthmaTh17 cellsIL-17Th17 responsesAsthma severity
2011
IFN-γ Acts on the Airway Epithelium To Inhibit Local and Systemic Pathology in Allergic Airway Disease
Mitchell C, Provost K, Niu N, Homer R, Cohn L. IFN-γ Acts on the Airway Epithelium To Inhibit Local and Systemic Pathology in Allergic Airway Disease. The Journal Of Immunology 2011, 187: 3815-3820. PMID: 21873527, PMCID: PMC3178669, DOI: 10.4049/jimmunol.1100436.Peer-Reviewed Original ResearchConceptsAirway epitheliumAllergic airway inflammationAllergic airway diseaseTh2 cell activationGoal of therapyProduction of IFNAdministration of medicationsSystemic side effectsAirway mucosal surfaceAirway epithelial cellsSites of inflammationIFN-γ actionAirway inflammationAirway obstructionPersistent asthmaRefractory asthmaAirway diseaseIFN-γRTh1 cellsPathological responseSystemic pathologyEffector functionsSide effectsBone marrowAsthma
2010
Rhinovirus Infection of Allergen-Sensitized and -Challenged Mice Induces Eotaxin Release from Functionally Polarized Macrophages
Nagarkar DR, Bowman ER, Schneider D, Wang Q, Shim J, Zhao Y, Linn MJ, McHenry CL, Gosangi B, Bentley JK, Tsai WC, Sajjan US, Lukacs NW, Hershenson MB. Rhinovirus Infection of Allergen-Sensitized and -Challenged Mice Induces Eotaxin Release from Functionally Polarized Macrophages. The Journal Of Immunology 2010, 185: 2525-2535. PMID: 20644177, PMCID: PMC3208235, DOI: 10.4049/jimmunol.1000286.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticBronchial HyperreactivityChemokine CCL11CytokinesEosinophilsHeLa CellsHumansImmunohistochemistryInflammationInflammation MediatorsLungMacrophages, AlveolarMiceMice, Inbred BALB CMicroscopy, ConfocalOvalbuminPicornaviridae InfectionsReverse Transcriptase Polymerase Chain ReactionRhinovirusConceptsAllergic airway diseaseEotaxin-1Asthma exacerbationsAirway diseaseIL-4Eosinophilic inflammationRhinovirus infectionRV infectionLung macrophagesVirus-induced asthma exacerbationsBALB/c miceEotaxin-1/CCL11Airway eosinophilic inflammationRV-infected miceIL-4 productionVirus-infected miceHuman rhinovirus infectionDepletion of macrophagesCD68-positive cellsMacrophage activation statusRhinovirus serotype 1BAirway responsivenessCholinergic hyperresponsivenessRV inoculationAirway eosinophiliaAirway epithelium response to IFN-γ regulates allergic airway inflammation (91.7)
Mitchell C, Provost K, Niu N, Homer R, Cohn L. Airway epithelium response to IFN-γ regulates allergic airway inflammation (91.7). The Journal Of Immunology 2010, 184: 91.7-91.7. DOI: 10.4049/jimmunol.184.supp.91.7.Peer-Reviewed Original ResearchAirway epithelial cellsAllergic airway inflammationAllergic airway diseaseAirway eosinophiliaAirway inflammationAirway diseaseNon-hematopoietic cellsEpithelial cellsIFN-γRIFN-γ receptor-deficient miceIFN-γR expressionReceptor-deficient miceBone marrow chimerasOVA-specific Th1Th1 cellsDeficient miceMucus productionBone marrowEpithelium responseIFNMaximal inhibitionEosinophiliaInflammationMiceInhibitory effect
2006
Oral Bromelain Attenuates Inflammation in an Ovalbumin‐Induced Murine Model of Asthma
Secor ER, Carson WF, Singh A, Pensa M, Guernsey LA, Schramm CM, Thrall RS. Oral Bromelain Attenuates Inflammation in an Ovalbumin‐Induced Murine Model of Asthma. Evidence-based Complementary And Alternative Medicine 2006, 5: 61-69. PMID: 18317550, PMCID: PMC2249734, DOI: 10.1093/ecam/nel110.Peer-Reviewed Original ResearchAcute allergic airway diseaseMurine modelAAD miceOral bromelainMethacholine sensitivityTh2 cytokines IL-5OVA aerosol challengeOVA/alumAllergic airway diseaseFemale C57BL/6J miceIL-13 concentrationsCytokines IL-5Beneficial therapeutic effectsAirway reactivityOVA aerosolLung histologyAirway diseaseBAL eosinophilsOral treatmentAerosol challengeImmunomodulatory effectsIL-13C57BL/6J miceIL-5T cells
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