2006
LFA-1-Dependent HuR Nuclear Export and Cytokine mRNA Stabilization in T Cell Activation
Wang JG, Collinge M, Ramgolam V, Ayalon O, Fan XC, Pardi R, Bender JR. LFA-1-Dependent HuR Nuclear Export and Cytokine mRNA Stabilization in T Cell Activation. The Journal Of Immunology 2006, 176: 2105-2113. PMID: 16455966, DOI: 10.4049/jimmunol.176.4.2105.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAntigens, SurfaceBase SequenceCD28 AntigensCell NucleusCells, CulturedCytokinesCytoplasmELAV ProteinsELAV-Like Protein 1HumansLymphocyte ActivationLymphocyte Function-Associated Antigen-1Molecular Sequence DataRNA StabilityRNA, MessengerRNA, Small InterferingRNA-Binding ProteinsT-LymphocytesConceptsNuclear exportAU-rich element (ARE) sequenceMRNA stabilizationClass II AU-rich elementsT cell activationAU-rich elementsLymphokine gene expressionRapid nuclearRegulated processIntegrin engagementCell activationMRNA reporterRNA interferenceHuR functionIntegrin LFA-1MRNA stabilityGene expressionProtein productionHuman peripheral T cellsCytoplasmic translocationGM-CSF mRNAElement sequencesProtein HuRHuR levelsLFA-1
1999
Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice
Shao C, Deng L, Henegariu O, Liang L, Raikwar N, Sahota A, Stambrook P, Tischfield J. Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 9230-9235. PMID: 10430925, PMCID: PMC17762, DOI: 10.1073/pnas.96.16.9230.Peer-Reviewed Original ResearchMeSH KeywordsAdenine PhosphoribosyltransferaseAnimalsChromosome MappingCrosses, GeneticEar, ExternalExonsFemaleFibroblastsGenes, RecessiveGenetic VariationHeterozygoteHumansLoss of HeterozygosityMaleMiceMice, Inbred C3HMice, Inbred StrainsMice, Mutant StrainsMutagenesisPoint MutationRecombination, GeneticSkinT-LymphocytesConceptsMitotic recombinationPolymorphic molecular markersSomatic cell variantsProgeny of crossesFrequency of crossoversHigh spontaneous frequencyAPRT enzyme activitySomatic mutagenesisMap distanceCytological markersSelection mediumHuman peripheral T cellsMolecular markersChromosome 8Vivo lossCell coloniesAPRTEnzyme activityNormal fibroblastsRecombinationHeterozygous micePeripheral T cellsAdenine analogueHeterozygote miceVivo
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