1986
Rat growth hormone gene expression is correlated with an unmethylated CGCG sequence near the transcription initiation site.
Strobl J, Dannies P, Thompson E. Rat growth hormone gene expression is correlated with an unmethylated CGCG sequence near the transcription initiation site. Biochemistry 1986, 25: 3640-8. PMID: 3013292, DOI: 10.1021/bi00360a025.Peer-Reviewed Original ResearchConceptsTranscription initiation siteInitiation siteGene expressionRat growth hormone gene expressionMethylation-sensitive restriction enzymesRat growth hormone geneHybrid cellsGene control regionsGrowth hormone geneThai sitesGrowth hormone gene expressionGH3 cellsCGCG sequenceControl regionDNA methylationBp 5Gene regionGH geneHormone geneHormone gene expressionRestriction enzymesMethylation statusRestriction sitesMouse fibroblastsGH gene expression
1985
Individual interphase chromosome domains revealed by in situ hybridization
Manuelidis L. Individual interphase chromosome domains revealed by in situ hybridization. Human Genetics 1985, 71: 288-293. PMID: 3908288, DOI: 10.1007/bf00388453.Peer-Reviewed Original ResearchConceptsInterphase chromosomesHuman chromosomesMouse-human cell hybridsCharacteristic folding patternSingle human chromosomeHuman interphase chromosomesSitu hybridizationHuman DNA probesInterphase chromosome domainsChromosome domainsIndividual chromosomesCell hybridsInterphase nucleiChromosomesDNA probesHybrid cellsFolding patternInterphase domainHybridizationOptical sectionsDomainNucleusWide fibersHybridization solutionReproducible position
1982
Somatic cell hybridization of growth hormone-producing rat pituitary cells and mouse fibroblasts results in extinction of growth hormone expression via a defect in growth hormone RNA production.
Strobl J, Dannies P, Thompson E. Somatic cell hybridization of growth hormone-producing rat pituitary cells and mouse fibroblasts results in extinction of growth hormone expression via a defect in growth hormone RNA production. Journal Of Biological Chemistry 1982, 257: 6588-6594. PMID: 6176584, DOI: 10.1016/s0021-9258(20)65183-3.Peer-Reviewed Original ResearchConceptsMouse GH geneGH geneHybrid cellsHybrid cell DNAHigh molecular weight precursorNon-pituitary cellsSomatic cell hybridizationMolecular weight precursorMultiple restriction enzymesStructural geneTranscript degradationMature mRNARestriction enzyme analysisIncomplete transcriptsFlanking sequencesParental cell lineTranscriptional blockRestriction enzyme digestionRNA productionSouthern hybridizationCell hybridizationMRNA sequencesFibroblasts resultsGrowth hormone expressionMouse fibroblast cells
1980
Pigmentation and tumorigenicity of reconstituted, cybrid and hybrid mouse cells
Halaban R, Moellmann G, Godawska E, Eisenstadt J. Pigmentation and tumorigenicity of reconstituted, cybrid and hybrid mouse cells. Experimental Cell Research 1980, 130: 427-435. PMID: 7449860, DOI: 10.1016/0014-4827(80)90021-x.Peer-Reviewed Original ResearchConceptsWhole cellsHybrid cellsSuppression of tumorigenicityMelanoma genomeMelanocytic functionNon-tumorigenic fibroblastsDonor parentMouse cellsCybridsStable expressionCytoplasmic transferCellular fragmentsTumorigenicityExpressionCytoplastsCellsViral particlesMurine melanomaGenomeChromosomesNucleoplastsPhenotypeExtinctionComparable numberPigmentation
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