2022
COVID-19 and Preexisting Comorbidities: Risks, Synergies, and Clinical Outcomes
Bigdelou B, Sepand M, Najafikhoshnoo S, Negrete J, Sharaf M, Ho J, Sullivan I, Chauhan P, Etter M, Shekarian T, Liang O, Hutter G, Esfandiarpour R, Zanganeh S. COVID-19 and Preexisting Comorbidities: Risks, Synergies, and Clinical Outcomes. Frontiers In Immunology 2022, 13: 890517. PMID: 35711466, PMCID: PMC9196863, DOI: 10.3389/fimmu.2022.890517.Peer-Reviewed Original ResearchConceptsCo-existing diseasesOptimal management of patientsManagement of patientsCOVID-19 clinical outcomesHost-viral interactionsClinical outcomesSevere acute respiratory syndrome coronavirus 2Severe infectionsMinimal symptomsAcute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Immune responseOptimal managementPutative signaling pathwaysSyndrome coronavirus 2Cardiovascular diseaseSevere outcomesCoronavirus disease 2019PatientsSARS-CoV-2Medical consequencesDiseaseSignaling pathwayCoronavirus 2COVID-19
2021
Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes
Ravindra NG, Alfajaro MM, Gasque V, Huston NC, Wan H, Szigeti-Buck K, Yasumoto Y, Greaney AM, Habet V, Chow RD, Chen JS, Wei J, Filler RB, Wang B, Wang G, Niklason LE, Montgomery RR, Eisenbarth SC, Chen S, Williams A, Iwasaki A, Horvath TL, Foxman EF, Pierce RW, Pyle AM, van Dijk D, Wilen CB. Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes. PLOS Biology 2021, 19: e3001143. PMID: 33730024, PMCID: PMC8007021, DOI: 10.1371/journal.pbio.3001143.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionSARS-CoV-2Human bronchial epithelial cellsInterferon-stimulated genesCell state changesAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSyndrome coronavirus 2 infectionCell tropismCoronavirus 2 infectionCoronavirus disease 2019Onset of infectionCell-intrinsic expressionCourse of infectionAir-liquid interface culturesHost-viral interactionsBronchial epithelial cellsSingle-cell RNA sequencingCell typesIL-1Disease 2019Human airwaysDevelopment of therapeuticsDrug AdministrationViral replication
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