1999
Herpes Simplex Virus (HSV)-Mediated ICAM-1 Gene Transfer Abrogates Tumorigenicity and Induces Anti-Tumor Immunity
D’Angelica M, Tung C, Allen P, Halterman M, Delman K, Delohery T, Klimstra D, Brownlee M, Federoff H, Fong Y. Herpes Simplex Virus (HSV)-Mediated ICAM-1 Gene Transfer Abrogates Tumorigenicity and Induces Anti-Tumor Immunity. Molecular Medicine 1999, 5: 606-616. PMID: 10551902, PMCID: PMC2230459, DOI: 10.1007/bf03402073.Peer-Reviewed Original ResearchConceptsIntercellular adhesion molecule-1Surface expression of adhesion moleculesExpression of adhesion moleculesTumor cellsCell surface expressionAmplicon vectorsAdhesion moleculesHigh-level cell surface expressionInduce anti-tumor immunityTransplantable rat hepatocellular carcinomaCell surface ICAM-1 expressionSurface expressionCell surface expression of adhesion moleculesExposure of tumor cellsExpression of intercellular adhesion molecule-1Immune response to cancerSurface ICAM-1 expressionAnti-tumor immunityAnti-tumor responsesParental tumor cellsHuman colorectal cancer cell linesHuman intercellular adhesion molecule-1Increased tumor expressionICAM-1 expressionHerpes simplex virus
1994
Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection.
Fodor W, Williams B, Matis L, Madri J, Rollins S, Knight J, Velander W, Squinto S. Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 11153-11157. PMID: 7526391, PMCID: PMC45185, DOI: 10.1073/pnas.91.23.11153.Peer-Reviewed Original ResearchConceptsHuman complement inhibitorsHyperacute rejectionComplement inhibitorsAnti-porcine antibodiesTerminal complement inhibitorTransgenic pigsXenogeneic transplantation modelPorcine cell typesHigh-level cell surface expressionVariety of murineXenogeneic complementsXenogeneic organ transplantationGraft failureOrgan rejectionVessel occlusionCell surface expressionHyperacute organ rejectionTransplantation modelOrgan transplantationXenogeneic organsVascular endotheliumTransgenic miceSerum complementAutologous complementTransplantation
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