2024
868 AXL restricts cholesterol mobilization, modulating dendritic cell maturation and the immune response to cancer
Belabed M, Park M, Blouin C, Balan S, Moon C, Boumelha J, Peros A, Mattiuz R, Reid A, Azimi C, LaMarche N, Troncoso L, Berichel J, Wilk M, Brown B, Radford K, Ghosh S, Rothlin C, Yvan-Charvet L, Marron T, Puleston D, Bhardwaj N, Lamaze C, Merad M. 868 AXL restricts cholesterol mobilization, modulating dendritic cell maturation and the immune response to cancer. 2024, a982-a982. DOI: 10.1136/jitc-2024-sitc2024.0868.Peer-Reviewed Original ResearchImmune response to cancerDendritic cell maturationResponse to cancerCell maturationCholesterol mobilization
2021
CD8 T cell differentiation in cancer is comprised of two distinct phases
Prokhnevska N, Cardenas M, Valanparambil R, Jansen C, Master V, Sanda M, Kissick H. CD8 T cell differentiation in cancer is comprised of two distinct phases. The Journal Of Immunology 2021, 206: 57.04-57.04. DOI: 10.4049/jimmunol.206.supp.57.04.Peer-Reviewed Original ResearchTumor-specific CD8 T cellsTumor-draining lymph nodesCD8 T cellsCD8 T cell differentiationResponse to tumorsT cellsT cell differentiationStem-like CD8 T cellsT cell responses to tumorsUndifferentiated phenotypeImmune response to tumorsSubsets of CD8 T cellsCD8 T cell subsetsImmune response to cancerTumor-specific antigensProstate cancer modelT cell subsetsHuman prostate cancerDraining Lymph NodesResponse to cancerCD8 infiltrationLCMV glycoproteinProstate cancerLymph nodesCD8
1999
Herpes Simplex Virus (HSV)-Mediated ICAM-1 Gene Transfer Abrogates Tumorigenicity and Induces Anti-Tumor Immunity
D’Angelica M, Tung C, Allen P, Halterman M, Delman K, Delohery T, Klimstra D, Brownlee M, Federoff H, Fong Y. Herpes Simplex Virus (HSV)-Mediated ICAM-1 Gene Transfer Abrogates Tumorigenicity and Induces Anti-Tumor Immunity. Molecular Medicine 1999, 5: 606-616. PMID: 10551902, PMCID: PMC2230459, DOI: 10.1007/bf03402073.Peer-Reviewed Original ResearchConceptsIntercellular adhesion molecule-1Surface expression of adhesion moleculesExpression of adhesion moleculesTumor cellsCell surface expressionAmplicon vectorsAdhesion moleculesHigh-level cell surface expressionInduce anti-tumor immunityTransplantable rat hepatocellular carcinomaCell surface ICAM-1 expressionSurface expressionCell surface expression of adhesion moleculesExposure of tumor cellsExpression of intercellular adhesion molecule-1Immune response to cancerSurface ICAM-1 expressionAnti-tumor immunityAnti-tumor responsesParental tumor cellsHuman colorectal cancer cell linesHuman intercellular adhesion molecule-1Increased tumor expressionICAM-1 expressionHerpes simplex virus
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