2025
472. Role of Voltage-Gated Calcium Channels in Vulnerable Pyramidal Neurons in Primate Dorsolateral Prefrontal Cortex: Elucidating the Role of Cav3.1 and Cav1.2 in Higher-Order Cognition
Datta D, Yang S, Gonzalez-Burgos G, Enwright J, Arion D, Lewis D, Wang M, Arnsten A. 472. Role of Voltage-Gated Calcium Channels in Vulnerable Pyramidal Neurons in Primate Dorsolateral Prefrontal Cortex: Elucidating the Role of Cav3.1 and Cav1.2 in Higher-Order Cognition. Biological Psychiatry 2025, 97: s291-s292. DOI: 10.1016/j.biopsych.2025.02.710.Peer-Reviewed Original ResearchSUSCEPTIBLE PYRAMIDAL NEURONS IN PRIMATE DORSOLATERAL PREFRONTAL CORTEX EXPRESS AN ENRICHED CALCIUM INTERACTOME: CRITICAL ROLE OF CALBINDIN AND CAV1.2 IN HIGHER-ORDER COGNITION
Datta *, Yang S, Joyce M, Woo E, McCarroll S, Gonzalez-Burgos G, Perone I, Uchendu S, Ling E, Goldman R, Berretta S, Murray J, Morozov Y, Arellano J, Duque A, Rakic P, O'dell R, van Dyck C, Lewis D, Wang M, Krienen F, Arnsten A. SUSCEPTIBLE PYRAMIDAL NEURONS IN PRIMATE DORSOLATERAL PREFRONTAL CORTEX EXPRESS AN ENRICHED CALCIUM INTERACTOME: CRITICAL ROLE OF CALBINDIN AND CAV1.2 IN HIGHER-ORDER COGNITION. The International Journal Of Neuropsychopharmacology 2025, 28: i57-i58. PMCID: PMC11814899, DOI: 10.1093/ijnp/pyae059.100.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexMacaque dlPFCPrefrontal cortexWorking memoryLayer 3 pyramidal cellsAlzheimer s diseasePrefrontal cortex dysfunctionExpression of Grin2bPyramidal cellsHigher-order cognitionIncreased risk of mental disordersRisk of neuropsychiatric disordersDendritic spine pathologyRisk of mental disordersIncreased risk of neuropsychiatric disordersL-type calcium channel Cav1.2Primate dlPFCDLPFC functionCognitive deficitsLayer III pyramidal cellsMemory impairmentPsychiatric disordersBrain circuitryNeuropsychiatric disordersMental representations
2024
Interplay between preclinical indices of obesity and neural signatures of fluid intelligence in youth
Ward T, Schantell M, Dietz S, Ende G, Rice D, Coutant A, Arif Y, Wang Y, Calhoun V, Stephen J, Heinrichs-Graham E, Taylor B, Wilson T. Interplay between preclinical indices of obesity and neural signatures of fluid intelligence in youth. Communications Biology 2024, 7: 1285. PMID: 39379610, PMCID: PMC11461743, DOI: 10.1038/s42003-024-06924-w.Peer-Reviewed Original ResearchConceptsAbstract reasoning taskFluid intelligenceAbstract reasoningBrain regionsNeural activityReasoning tasksLeft dorsolateral prefrontal cortexLeft temporoparietal junctionDorsolateral prefrontal cortexHigher-order cognitionWhole-brain correlationHigh-density magnetoencephalographySignificant oscillatory responsesYouth aged 9Prefrontal cortexTemporoparietal junctionNeural signaturesTheta oscillationsResponse scaleWhole-brainNeurobehavioral functionNeural dynamicsAged 9CognitionReaction time
2023
Metacognitive judgments during visuomotor learning reflect the integration of error history
Hewitson C, Al-Fawakhiri N, Forrence A, McDougle S. Metacognitive judgments during visuomotor learning reflect the integration of error history. Journal Of Neurophysiology 2023, 130: 264-277. PMID: 37377281, DOI: 10.1152/jn.00022.2023.Peer-Reviewed Original ResearchConceptsConfidence judgmentsMetacognitive judgmentsMotor learningMotor errorsVisuomotor learningHigher-order cognitionMetacognitive confidence judgmentsRange of tasksMetacognitive representationExplicit motorNeural studiesComputational modeling approachOwn abilityEnvironmental volatilityPeople's confidenceJudgmentsMotor controlLearning environmentLearningConfidence estimatesDescriptive modelError historyComputational modelingError costsCognition
2012
The COMT Val/Met polymorphism is associated with reading‐related skills and consistent patterns of functional neural activation
Landi N, Frost SJ, Mencl WE, Preston JL, Jacobsen LK, Lee M, Yrigollen C, Pugh KR, Grigorenko EL. The COMT Val/Met polymorphism is associated with reading‐related skills and consistent patterns of functional neural activation. Developmental Science 2012, 16: 13-23. PMID: 23278923, PMCID: PMC3655431, DOI: 10.1111/j.1467-7687.2012.01180.x.Peer-Reviewed Original ResearchConceptsFunctional neural activationCOMT Val/Met polymorphismVal/Met polymorphismNeural activationReading-related skillsHigher-order cognitionMet polymorphismGood readersReading measuresReading skillsAdequate intelligenceCognitionSkillsCOMT geneBroad effectsIndividualsConsistent patternIntelligenceReadingChildrenAdultsDisabilityMeasuresRs4680Substantial portion
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