Multiomic profiling of LRRC15 in triple negative breast cancer (TNBC).
Morgenstern Kaplan D, Deshmukh S, Wu S, Xiu J, Lopes G, Valdes F, King T, George S, Hurley J, Salazar A, Sucre S, Trapani D, Advani P, Jayachandran P, Lustberg M, Sledge G, Barreto Coelho P. Multiomic profiling of LRRC15 in triple negative breast cancer (TNBC). Journal Of Clinical Oncology 2025, 43: 1098-1098. DOI: 10.1200/jco.2025.43.16_suppl.1098.Peer-Reviewed Original ResearchTriple negative breast cancerCancer-associated fibroblastsImmune cell fractionsH tumorsOverall survivalTumor microenvironmentT cellsHigher expression of immune checkpoint genesAbundance of cancer-associated fibroblastsTNBC heterogeneityExpression of immune checkpoint genesIncreased CAFsT cell inflamed scoreAssociated with better OSCD8+ T cellsInfiltration of B cellsReal-world overall survivalAnalysis of immune cellsFrequency of PIK3CAPositive predictive biomarkerPD-L1 positivityAssociated with poor prognosisImmune checkpoint genesTreatment-related survivalAdverse prognostic biomarkerChemokines as predictive biomarkers for immune checkpoint inhibitor (ICI) efficacy in triple negative breast cancer (TNBC).
Gandhi S, Deshmukh S, Wu S, Xiu J, Lesinski G, Paulos C, Czerniecki B, Chalasani P, Yao S, Ernstoff M, Chumsri S, Trapani D, Leone J, Lustberg M, Sledge G, Kalinsky K, Kalinski P. Chemokines as predictive biomarkers for immune checkpoint inhibitor (ICI) efficacy in triple negative breast cancer (TNBC). Journal Of Clinical Oncology 2025, 43: 1106-1106. DOI: 10.1200/jco.2025.43.16_suppl.1106.Peer-Reviewed Original ResearchTriple negative breast cancerImmune checkpoint inhibitorsTumor mutational burdenTumor microenvironmentCXCR3 expressionBreast cancerHER2+Overall survivalPredictive biomarkersHigher expression of immune checkpoint genesExpression of immune checkpoint genesImmune checkpoint inhibitor pembrolizumabT cell inflamed scoreImmune checkpoint inhibitor efficacyAssociated with longer survivalReal-world overall survivalCognate receptor CXCR3Enhance ICI efficacyPD-L1 positivityT cell infiltrationImmune checkpoint genesAggressive breast cancerNegative breast cancerTumor microenvironment characteristicsImmune cell fractions
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply