Distinct pathways of pathogenesis of intraductal oncocytic papillary neoplasms and intraductal papillary mucinous neoplasms of the pancreas
Basturk O, Chung S, Hruban R, Adsay N, Askan G, Iacobuzio-Donahue C, Balci S, Zee S, Memis B, Shia J, Klimstra D. Distinct pathways of pathogenesis of intraductal oncocytic papillary neoplasms and intraductal papillary mucinous neoplasms of the pancreas. Virchows Archiv 2016, 469: 523-532. PMID: 27591765, PMCID: PMC5083199, DOI: 10.1007/s00428-016-2014-x.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmIntraductal oncocytic papillary neoplasmPapillary mucinous neoplasmMucinous neoplasmsClaudin-4Papillary neoplasmDuctal adenocarcinomaB-catenin expressionExpression of mesothelinLesions expressed MUC5ACResults of immunolabelingNuclear p53 accumulationPancreatic ductal neoplasmsIntraductal componentSMAD4 lossHepPar-1Tumor typesDuctal neoplasmsGenetic alterationsMUC proteinsP53 accumulationNeoplasmsNeoplastic cellsDifferentiation markersMesothelin
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