2009
Immunohistochemistry as First-line Screening for Detecting Colorectal Cancer Patients at Risk for Hereditary Nonpolyposis Colorectal Cancer Syndrome
Shia J, Tang L, Vakiani E, Guillem J, Stadler Z, Soslow R, Katabi N, Weiser M, Paty P, Temple L, Nash G, Wong W, Offit K, Klimstra D. Immunohistochemistry as First-line Screening for Detecting Colorectal Cancer Patients at Risk for Hereditary Nonpolyposis Colorectal Cancer Syndrome. The American Journal Of Surgical Pathology 2009, 33: 1639-1645. PMID: 19701074, DOI: 10.1097/pas.0b013e3181b15aa2.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdenocarcinomaAdenosine TriphosphatasesBiomarkers, TumorColorectal Neoplasms, Hereditary NonpolyposisDNA Mismatch RepairDNA Repair EnzymesDNA-Binding ProteinsHumansImmunoenzyme TechniquesMass ScreeningMiddle AgedMismatch Repair Endonuclease PMS2MutationMutL Protein Homolog 1MutS Homolog 2 ProteinNeoplasm ProteinsNuclear ProteinsPredictive Value of TestsProspective StudiesRetrospective StudiesConceptsHereditary nonpolyposis colorectal cancerConcurrent loss of MSH2Hereditary nonpolyposis colorectal cancer syndromeHigher-than-average riskRevised Bethesda GuidelinesColorectal cancer syndromeNonpolyposis colorectal cancerIsolated loss of PMS2Colorectal cancerConcurrent loss of MLH1Mismatch repair protein abnormalitiesLoss of PMS2Loss of MLH1Screening colorectal cancerBethesda guidelinesLoss of MSH2Cancer syndromesDetecting colorectal cancer patientsFirst-line screeningYears of ageColorectal cancer patientsMismatch repair proteinsMSH6PMS2Clinical setting
2008
Adenoma-infiltrating Lymphocytes (AILs) are a Potential Marker of Hereditary Nonpolyposis Colorectal Cancer
Polydorides A, Mukherjee B, Gruber S, McKenna B, Appelman H, Greenson J. Adenoma-infiltrating Lymphocytes (AILs) are a Potential Marker of Hereditary Nonpolyposis Colorectal Cancer. The American Journal Of Surgical Pathology 2008, 32: 1661-1666. PMID: 18753941, PMCID: PMC3500084, DOI: 10.1097/pas.0b013e31816ffa80.Peer-Reviewed Original ResearchConceptsHereditary nonpolyposis colorectal cancer syndromeColorectal adenomasControl adenomasHereditary nonpolyposis colorectal cancer patientsColorectal cancer syndromePresence of high-grade dysplasiaTumor-infiltrating lymphocytesHigh-grade dysplasiaPresence of necrosisNumbers of mitotic figuresColorectal cancer patientsHost immune responseVillous componentCancer syndromesLack of dirty necrosisSerrated architectureMicrosatellite-unstable colorectal cancersPatient ageGeneral populationPoor differentiationDirty necrosisInexpensive markerHistological featuresColorectal cancerAdenomas
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