2024
Drug-Induced Thrombocytopenia: A Critical Condition in Hospitalized Cancer Patients
Abouelkheer Y, Ranat R, Phuong L, Boxer D, Ahasic A. Drug-Induced Thrombocytopenia: A Critical Condition in Hospitalized Cancer Patients. Blood 2024, 144: 5544-5544. DOI: 10.1182/blood-2024-211937.Peer-Reviewed Original ResearchDrug-induced thrombocytopeniaHigh risk of bleedingPlatelet factor 4Risk of bleedingPlatelet countPostoperative dayIntravenous immunoglobulinSurgical cancer patientsCancer patientsSevere thrombocytopeniaCase of severe thrombocytopeniaRecovery of platelet countsHigh riskEtiology of thrombocytopeniaBone marrow suppressionClear-cell carcinomaHeparin-Induced ThrombocytopeniaDisseminated intravascular coagulopathyImmune-mediated conditionsPostoperative day 3Postoperative day 7Consumption of plateletsPlanned surgical resectionPlatelet factor 4 antigenAdministration of dexamethasone
2020
Association of Heparin Dose, Route, Timing, and Duration With Heparin-Induced Thrombocytopenia
Crow JR, Nam L, Chasler JE, Ong CS, Dane KE, Kickler T, Lawton J, Streiff MB, Alejo D, Canner JK, Schena S. Association of Heparin Dose, Route, Timing, and Duration With Heparin-Induced Thrombocytopenia. The Annals Of Thoracic Surgery 2020, 112: 32-37. PMID: 33217393, DOI: 10.1016/j.athoracsur.2020.09.033.Peer-Reviewed Original ResearchConceptsCardiac surgery patientsAdult cardiac surgery patientsSurgery patientsUFH doseHeparin doseRetrospective case-control studyMultivariable conditional logistic regressionCardiopulmonary bypass durationHIT-positive patientsPrevalence of heparinUnfractionated heparin doseHeparin-Induced ThrombocytopeniaReceiver-operating characteristic curveCase-control studyConditional logistic regressionBypass durationIntravenous UFHUFH administrationUFH infusionSubcutaneous routeContinuous infusionMean agePatientsTotal doseLogistic regression
2017
Incidence and Outcomes of Heparin-Induced Thrombocytopenia in Patients Undergoing Transcatheter Aortic Valve Replacement
Telila T, Akintoye E, Ando T, Merid O, Mallikethi-Reddy S, Briasoulis A, Grines C, Afonso L. Incidence and Outcomes of Heparin-Induced Thrombocytopenia in Patients Undergoing Transcatheter Aortic Valve Replacement. The American Journal Of Cardiology 2017, 120: 300-303. PMID: 28576265, DOI: 10.1016/j.amjcard.2017.04.028.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overAnticoagulantsAortic Valve StenosisFemaleHeparinHospital MortalityHumansIncidenceKaplan-Meier EstimateMalePostoperative ComplicationsPrognosisRetrospective StudiesRisk FactorsSurvival RateThrombocytopeniaThromboembolismTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsVenous thrombosis/pulmonary embolismAcute kidney injuryHospital-level characteristicsHospital stayHospital mortalityKidney injuryPulmonary embolismHospital costsTranscatheter aortic valve replacementNationwide Inpatient Sample databaseOutcomes of HITPerioperative thromboembolic complicationsLonger hospital stayOutcomes of patientsAortic valve replacementHeparin-Induced ThrombocytopeniaMedian hospital costsImpact of HITTAVR groupCumulative incidenceInpatient mortalitySecondary outcomesThromboembolic complicationsValve replacementCardiac surgery
2015
Clinical and laboratory characteristics associated with a high optical density anti-platelet factor 4 ELISA test
Lu B, Kudlowitz D, Gardner L. Clinical and laboratory characteristics associated with a high optical density anti-platelet factor 4 ELISA test. Journal Of Blood Medicine 2015, 6: 277-283. PMID: 26640392, PMCID: PMC4657791, DOI: 10.2147/jbm.s90179.Peer-Reviewed Original ResearchHigh-positive groupHeparin-Induced ThrombocytopeniaPF4 ELISADefinitive heparin-induced thrombocytopeniaRetrospective chart review of patientsChart review of patientsDiagnose heparin-induced thrombocytopeniaReview of patientsLow-positive groupRetrospective chart reviewImmune-mediated disordersFisher's exact testWilcoxon rank sum testUrban academic institutionHigh-positive patientsRank sum testNegative patientsLaboratory characteristicsPositive patientsClinical characteristicsClinical featuresExact testNegative groupClinical variablesHospital days
1985
Heparin-Induced Thrombocytopenia and Thrombosis: Detection and Specificity of a Platelet-Aggregating IgG
Sandler R, Seifer D, Morgan K, Pockros P, Wypych J, Weiss L, Schiffman S. Heparin-Induced Thrombocytopenia and Thrombosis: Detection and Specificity of a Platelet-Aggregating IgG. American Journal Of Clinical Pathology 1985, 83: 760-764. PMID: 4003343, DOI: 10.1093/ajcp/83.6.760.Peer-Reviewed Original ResearchConceptsMultiple arterial occlusionsResult of thrombocytopeniaHeparin-Induced ThrombocytopeniaSamples of serumPlatelet-aggregating factorCatastrophic syndromeWorst sequelaeAntithrombotic therapyHeparin therapyArterial occlusionArterial thrombosisIgG productionPresence of heparinNormal plateletsPlasma samplesHeparinThrombocytopeniaFurther studiesThrombosisTherapyIgGSequelaeSepticemiaSyndrome
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