Characterization of Indolent Chronic Myelomonocytic Leukemia Phenotypes and Dynamic Features of Disease Progression
Aguirre L, Ball S, Jain A, Ali N, Sallman D, Kuykendall A, Sweet K, Lancet J, Padron E, Komrokji R. Characterization of Indolent Chronic Myelomonocytic Leukemia Phenotypes and Dynamic Features of Disease Progression. Clinical Lymphoma Myeloma & Leukemia 2025, 25: 661-671. PMID: 40254502, DOI: 10.1016/j.clml.2025.03.016.Peer-Reviewed Original ResearchConceptsChronic myelomonocytic leukemia patientsChronic myelomonocytic leukemiaAbnormally localized immature precursorsRisk of progressionIndolent diseaseTreatment initiationAssociated with higher hemoglobinM:E ratioClonal hematopoietic disordersFeatures of disease progressionRUNX1 mutationsIndolent featuresJAK2 mutationMyelomonocytic leukemiaClinical presentationHematopoietic disordersPlatelet countDisease aggressivenessClonal evolutionLeukemia phenotypeLymphocyte/monocyte countsDisease behaviorHigher hemoglobinDisease progressionImmature precursors
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