2025
The Utility of a Critical Antibody Titer in Anti-K Alloimmunized Pregnancies: A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy
Jacobs J, Sugrue R, Federspiel J, Funaro M, Adkins B, Booth G, de Haas M, Ding J, Drndarevic D, Kabre S, Liu S, Slootweg Y, Tiblad E, Moise K, Abels E. The Utility of a Critical Antibody Titer in Anti-K Alloimmunized Pregnancies: A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy. Transfusion Medicine Reviews 2025, 39: 150895. PMID: 40253764, DOI: 10.1016/j.tmrv.2025.150895.Peer-Reviewed Original ResearchConceptsDiagnostic test accuracySevere HDFNMeta-analysisCases of severe HDFNInclusion criteriaAntibody titersTiter thresholdSevere hemolytic diseaseSystematic reviewMeta-analysis of diagnostic test accuracyAlloantibody levelsAlloimmunized pregnanciesFetal outcomesAlloimmunized patientsAntenatal surveillanceHemolytic diseaseAnti-KellClinical managementDiagnostic accuracyFetusesHDFNMaternal antibody titersSevere diseaseClinical guidelinesTiters
2024
Characterization of blood bank and transfusion medicine practices for pregnant individuals with fetuses at risk of hemolytic disease in the United States
Jacobs J, Booth G, Moise K, Adkins B, Bakhtary S, Fasano R, Goel R, Hinton H, Laghari S, Stephens L, Tormey C, Crowe E, Bloch E, Abels E. Characterization of blood bank and transfusion medicine practices for pregnant individuals with fetuses at risk of hemolytic disease in the United States. Transfusion 2024, 64: 1870-1880. PMID: 39248602, DOI: 10.1111/trf.18011.Peer-Reviewed Original ResearchRisk of HDFNAntigen testAntibody titersHemolytic diseaseRed blood cellsCell-free fetal DNA testingRisk of hemolytic diseaseCell-free fetal DNAMaternal antibody titersPregnant individualsFetal DNA testingBlood banksTransfusion medicine practiceFetal DNALaboratory testing practicesThird trimesterAntigen statusTransfusion medicine serviceAntigen resultsMedicine serviceFetusesHDFNCritical titerResponse rateDNA testing
2023
Passive transfer of alloantibodies through breast milk as a mediator of hemolytic anemia
Abels E, Jacobs J, Prior D, Willets L, Sostin N, Tormey C, Binns T. Passive transfer of alloantibodies through breast milk as a mediator of hemolytic anemia. Transfusion 2023, 63: 2188-2196. PMID: 37706556, DOI: 10.1111/trf.17548.Peer-Reviewed Original ResearchConceptsMaternal breast milkBreast milkNeonatal circulationRed blood cellsPassive transferAntiviral IgG antibodiesResolution of anemiaPaucity of dataNeonatal red blood cellsIntravenous immunoglobulinMaternal alloantibodiesMaternal antibodiesPlacental transferRBC antibodiesIgG antibodiesHemolytic diseaseHemolytic anemiaPlasma titersAlloantibodiesHDFNBlood cellsAntibodiesSignificant decreasePatientsAnemiaHemolytic disease of the fetus and newborn mediated by anti-Dia in a U.S. hospital
Jacobs J, Abels E, Binns T, Tormey C, Sostin N. Hemolytic disease of the fetus and newborn mediated by anti-Dia in a U.S. hospital. Immunohematology 2023, 39: 32-34. PMID: 37017601, DOI: 10.21307/immunohematology-2023-006.Peer-Reviewed Case Reports and Technical NotesConceptsHemolytic diseaseCases of HDFNU.S. hospitalsHemolytic transfusion reactionsDirect antiglobulin testNeonatal bilirubin levelsSouth American descentAntibody detection testsLow-prevalence antigensU.S. patient populationNear universal absenceHDFN casesBilirubin levelsPatient populationTransfusion reactionsAntiglobulin testUnexpected causeHispanic ethnicityBlood group systemAntigenAntibodiesHDFNHospitalFetusesDisease
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