1998
Dose-Dependence and Repeated-Dose Studies for Receptor/Gene-Mediated Pharmacodynamics of Methylprednisolone on Glucocorticoid Receptor Down-Regulation and Tyrosine Aminotransferase Induction in Rat Liver
Sun Y, DuBois D, Almon R, Pyszczynski N, Jusko W. Dose-Dependence and Repeated-Dose Studies for Receptor/Gene-Mediated Pharmacodynamics of Methylprednisolone on Glucocorticoid Receptor Down-Regulation and Tyrosine Aminotransferase Induction in Rat Liver. Journal Of Pharmacokinetics And Pharmacodynamics 1998, 26: 619-648. PMID: 10485078, DOI: 10.1023/a:1020746822634.Peer-Reviewed Original ResearchConceptsGR densityGR mRNADose-dependentlyTAT inductionTAT mRNAMale adrenalectomized Wistar ratsGlucocorticoid receptor messenger RNALevels of TAT mRNATAT activityDown-regulationRepeated-dose studyLow-dose groupReceptor messenger RNAAdrenalectomized Wistar ratsHigh-dose groupReceptor down-regulationConcentrations of methylprednisolonePharmacokinetic/pharmacodynamic (PK/PDInduction of TAT activityPlasma concentrations of methylprednisoloneIndirect response modelMethylprednisolone doseSteroid regimenHigh-doseRat liverFourth-Generation Model for Corticosteroid Pharmacodynamics: A Model for Methylprednisolone Effects on Receptor/Gene-Mediated Glucocorticoid Receptor Down-Regulation and Tyrosine Aminotransferase Induction in Rat Liver
Sun Y, DuBois D, Almon R, Jusko W. Fourth-Generation Model for Corticosteroid Pharmacodynamics: A Model for Methylprednisolone Effects on Receptor/Gene-Mediated Glucocorticoid Receptor Down-Regulation and Tyrosine Aminotransferase Induction in Rat Liver. Journal Of Pharmacokinetics And Pharmacodynamics 1998, 26: 289-317. PMID: 10098101, DOI: 10.1023/a:1023233409550.Peer-Reviewed Original ResearchConceptsGR densityMethylprednisolone doseTAT mRNADown-regulation of GR mRNABolus dose of methylprednisoloneMale adrenalectomized Wistar ratsTAT inductionGlucocorticoid receptorDown-regulationDose of methylprednisoloneADAPT II programEffects of corticosteroidsGR mRNA levelsReceptor down-regulationConcentrations of methylprednisoloneHepatic glucocorticoid receptorPlasma concentrations of methylprednisoloneIndirect response modelMethylprednisolone effectsActivated steroid-receptor complexesGR down-regulationCorticosteroid effectsSteroid-receptor complexGR mRNAPredose levels
1995
Third-generation model for corticosteroid pharmacodynamics: Roles of glucocorticoid receptor mRNA and tyrosine aminotransferase mRNA in rat liver
Xu Z, Sun Y, DuBois D, Almon R, Jusko W. Third-generation model for corticosteroid pharmacodynamics: Roles of glucocorticoid receptor mRNA and tyrosine aminotransferase mRNA in rat liver. Journal Of Pharmacokinetics And Pharmacodynamics 1995, 23: 163-181. PMID: 8719235, DOI: 10.1007/bf02354270.Peer-Reviewed Original ResearchConceptsGR messenger RNAGR down-regulationGR densityMale adrenalectomized Wistar ratsGlucocorticoid receptorMessenger RNAGlucocorticoid receptor messenger RNAReceptor messenger RNATyrosine aminotransferase activityEffects of corticosteroidsGR mRNA levelsConcentrations of methylprednisoloneDeclined to baselinePlasma concentrations of methylprednisoloneMethylprednisolone doseMethylprednisolone IVTyrosine aminotransferaseTerminal t1/2Corticosteroid effectsHepatic tyrosine aminotransferaseMethylprednisolonePharmacodynamic parametersWistar ratsPlasma concentrationsTyrosine aminotransferase induction
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