Third-generation model for corticosteroid pharmacodynamics: Roles of glucocorticoid receptor mRNA and tyrosine aminotransferase mRNA in rat liver
Xu Z, Sun Y, DuBois D, Almon R, Jusko W. Third-generation model for corticosteroid pharmacodynamics: Roles of glucocorticoid receptor mRNA and tyrosine aminotransferase mRNA in rat liver. Journal Of Pharmacokinetics And Pharmacodynamics 1995, 23: 163-181. PMID: 8719235, DOI: 10.1007/bf02354270.Peer-Reviewed Original ResearchConceptsGR messenger RNAGR down-regulationGR densityMale adrenalectomized Wistar ratsGlucocorticoid receptorMessenger RNAGlucocorticoid receptor messenger RNAReceptor messenger RNATyrosine aminotransferase activityEffects of corticosteroidsGR mRNA levelsConcentrations of methylprednisoloneDeclined to baselinePlasma concentrations of methylprednisoloneMethylprednisolone doseMethylprednisolone IVTyrosine aminotransferaseTerminal t1/2Corticosteroid effectsHepatic tyrosine aminotransferaseMethylprednisolonePharmacodynamic parametersWistar ratsPlasma concentrationsTyrosine aminotransferase induction
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