1999
The Role of Gonadotropin-Releasing Hormone in Murine Preimplantation Embryonic Development*
Raga F, Casañ E, Kruessel J, Wen Y, Bonilla-Musoles F, Polan M. The Role of Gonadotropin-Releasing Hormone in Murine Preimplantation Embryonic Development*. Endocrinology 1999, 140: 3705-3712. DOI: 10.1210/en.140.8.3705.Peer-Reviewed Original ResearchPreimplantation murine embryosGnRH antagonistBlastocyst stageGnRH agonistMurine embryosPreimplantation development of embryosEffects of GnRH antagonistsEmbryo developmentConcentrations of GnRH agonistGnRH receptor messenger RNAHatched blastocyst stageReceptor messenger RNAEarly stages of placentationGnRH receptor mRNAPreimplantation embryonic developmentStages of placentationAntagonist in vitroGonadotropin-releasing hormonePreimplantation developmentReceptor mRNAGnRH analogsGnRH receptorMouse embryosPreimplantationDevelopment of embryos
1998
Dose-Dependence and Repeated-Dose Studies for Receptor/Gene-Mediated Pharmacodynamics of Methylprednisolone on Glucocorticoid Receptor Down-Regulation and Tyrosine Aminotransferase Induction in Rat Liver
Sun Y, DuBois D, Almon R, Pyszczynski N, Jusko W. Dose-Dependence and Repeated-Dose Studies for Receptor/Gene-Mediated Pharmacodynamics of Methylprednisolone on Glucocorticoid Receptor Down-Regulation and Tyrosine Aminotransferase Induction in Rat Liver. Journal Of Pharmacokinetics And Pharmacodynamics 1998, 26: 619-648. PMID: 10485078, DOI: 10.1023/a:1020746822634.Peer-Reviewed Original ResearchConceptsGR densityGR mRNADose-dependentlyTAT inductionTAT mRNAMale adrenalectomized Wistar ratsGlucocorticoid receptor messenger RNALevels of TAT mRNATAT activityDown-regulationRepeated-dose studyLow-dose groupReceptor messenger RNAAdrenalectomized Wistar ratsHigh-dose groupReceptor down-regulationConcentrations of methylprednisolonePharmacokinetic/pharmacodynamic (PK/PDInduction of TAT activityPlasma concentrations of methylprednisoloneIndirect response modelMethylprednisolone doseSteroid regimenHigh-doseRat liver
1996
Expression and localization of transforming growth factor-beta receptors type I and type II in the rat ventral prostate during regression.
Kim I, Ahn H, Zelner D, Park L, Sensibar J, Lee C. Expression and localization of transforming growth factor-beta receptors type I and type II in the rat ventral prostate during regression. Endocrinology 1996, 10: 107-15. PMID: 8838150, DOI: 10.1210/mend.10.1.8838150.Peer-Reviewed Original ResearchConceptsReceptor messenger RNARat ventral prostateType II receptorII receptorsVentral prostateReceptor expressionDay 7Growth factor-beta receptor type IType III receptor expressionTGF betaTGF-beta receptor type IIType IType II receptor proteinType II receptor expressionMessenger RNAEffects of androgensTGF-beta signaling receptorsReceptor type IReceptor type IIStromal-epithelial interactionsType IIProstatic epithelial cellsGrowth factor beta receptorWestern blot analysisImmunohistochemical study
1995
Further evidence for a novel receptor for amino-terminal parathyroid hormone-related protein on keratinocytes and squamous carcinoma cell lines
Orloff J, Kats Y, Urena P, Schipani E, Vasavada R, Philbrick W, Behal A, Abou-Samra A, Segre G, Jüppner H. Further evidence for a novel receptor for amino-terminal parathyroid hormone-related protein on keratinocytes and squamous carcinoma cell lines. Endocrinology 1995, 136: 3016-3023. DOI: 10.1210/en.136.7.3016.Peer-Reviewed Original ResearchSquamous carcinoma cell linesType I receptorSquamous cell linesCarcinoma cell linesI receptorSquamous cellsCell linesPolyadenylated RNAPTH/PTHrP receptorCloned type I receptorsMessenger RNAAmino-terminal PTHPTH target tissuesComplementary DNAReceptor messenger RNAParathyroid hormone-related proteinRegion-specific DNA probesReceptor complementary DNAResponse to PTHrPSquamous carcinoma cellsHormone-related proteinHybridized to probesPTH-related peptideType II receptorRegion-specific probesFurther evidence for a novel receptor for amino-terminal parathyroid hormone-related protein on keratinocytes and squamous carcinoma cell lines
Orloff J, Kats Y, Urena P, Schipani E, Vasavada R, Philbrick W, Behal A, Abou-Samra A, Segre G, Jüppner H. Further evidence for a novel receptor for amino-terminal parathyroid hormone-related protein on keratinocytes and squamous carcinoma cell lines. Endocrinology 1995, 136: 3016-3023. PMID: 7789327, DOI: 10.1210/endo.136.7.7789327.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceBlotting, NorthernCarcinoma, Squamous CellCyclic AMPDNA ProbesGene ExpressionHumansKeratinocytesMolecular Sequence DataParathyroid HormoneParathyroid Hormone-Related ProteinPeptide FragmentsProteinsRadioligand AssayReceptor, Parathyroid Hormone, Type 1Receptors, Parathyroid HormoneRNA, MessengerTransfectionTumor Cells, CulturedConceptsSquamous carcinoma cell linesSquamous cell linesPTH/PTHrP receptorType I receptorCarcinoma cell linesI receptorSquamous cellsPTHrP receptorCell linesCommon PTH/PTHrP receptorParathyroid hormone-related proteinType INormal keratinocytesAmino-terminal PTHMessenger RNAHormone-related proteinReceptor messenger RNAPTH target tissuesIntracellular cAMP responseSqCC/Y1 cellsSquamous carcinoma cellsStrong RNA signalsReceptor complementary DNAType II receptorIntracellular calciumThird-generation model for corticosteroid pharmacodynamics: Roles of glucocorticoid receptor mRNA and tyrosine aminotransferase mRNA in rat liver
Xu Z, Sun Y, DuBois D, Almon R, Jusko W. Third-generation model for corticosteroid pharmacodynamics: Roles of glucocorticoid receptor mRNA and tyrosine aminotransferase mRNA in rat liver. Journal Of Pharmacokinetics And Pharmacodynamics 1995, 23: 163-181. PMID: 8719235, DOI: 10.1007/bf02354270.Peer-Reviewed Original ResearchConceptsGR messenger RNAGR down-regulationGR densityMale adrenalectomized Wistar ratsGlucocorticoid receptorMessenger RNAGlucocorticoid receptor messenger RNAReceptor messenger RNATyrosine aminotransferase activityEffects of corticosteroidsGR mRNA levelsConcentrations of methylprednisoloneDeclined to baselinePlasma concentrations of methylprednisoloneMethylprednisolone doseMethylprednisolone IVTyrosine aminotransferaseTerminal t1/2Corticosteroid effectsHepatic tyrosine aminotransferaseMethylprednisolonePharmacodynamic parametersWistar ratsPlasma concentrationsTyrosine aminotransferase induction
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply