Fourth-Generation Model for Corticosteroid Pharmacodynamics: A Model for Methylprednisolone Effects on Receptor/Gene-Mediated Glucocorticoid Receptor Down-Regulation and Tyrosine Aminotransferase Induction in Rat Liver
Sun Y, DuBois D, Almon R, Jusko W. Fourth-Generation Model for Corticosteroid Pharmacodynamics: A Model for Methylprednisolone Effects on Receptor/Gene-Mediated Glucocorticoid Receptor Down-Regulation and Tyrosine Aminotransferase Induction in Rat Liver. Journal Of Pharmacokinetics And Pharmacodynamics 1998, 26: 289-317. PMID: 10098101, DOI: 10.1023/a:1023233409550.Peer-Reviewed Original ResearchConceptsGR densityMethylprednisolone doseTAT mRNADown-regulation of GR mRNABolus dose of methylprednisoloneMale adrenalectomized Wistar ratsTAT inductionGlucocorticoid receptorDown-regulationDose of methylprednisoloneADAPT II programEffects of corticosteroidsGR mRNA levelsReceptor down-regulationConcentrations of methylprednisoloneHepatic glucocorticoid receptorPlasma concentrations of methylprednisoloneIndirect response modelMethylprednisolone effectsActivated steroid-receptor complexesGR down-regulationCorticosteroid effectsSteroid-receptor complexGR mRNAPredose levels
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