SLC10A7 regulates O-GalNAc glycosylation and Ca2+ homeostasis in the secretory pathway: insights into SLC10A7-CDG
Durin Z, Layotte A, Morelle W, Houdou M, Folcher A, Legrand D, Lefeber D, Prevarskaya N, Von Blume J, Cormier-Daire V, Foulquier F. SLC10A7 regulates O-GalNAc glycosylation and Ca2+ homeostasis in the secretory pathway: insights into SLC10A7-CDG. Cellular And Molecular Life Sciences 2025, 82: 40. PMID: 39779512, PMCID: PMC11711720, DOI: 10.1007/s00018-024-05551-2.Peer-Reviewed Original ResearchConceptsCongenital disorders of glycosylationGlycan synthesisCa2+ homeostasisGolgi glycosylation defectsO-GalNAc glycosylationO-glycosylation defectRegulation of Ca2+ homeostasisGolgi transmembrane proteinCongenital disorders of glycosylation patientsDisorders of glycosylationGolgi homeostasisGolgi localizationGolgi compartmentSecretory pathwayHAP1 cellsProtein familyPatient fibroblastsGlycosylation defectsTransmembrane proteinsGalNAc residuesTransporter familyTight regulationGolgiGlycosylation abnormalitiesSLC10A7
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