Association of Somatic TET2 Mutations With Giant Cell Arteritis
Robinette M, Weeks L, Kramer R, Agrawal M, Gibson C, Yu Z, Sekar A, Mehta A, Niroula A, Brown J, McDermott G, Reshef E, Lu J, Liou V, Chiou C, Natarajan P, Freitag S, Rao D, Ebert B. Association of Somatic TET2 Mutations With Giant Cell Arteritis. Arthritis & Rheumatology 2024, 76: 438-443. PMID: 37909388, PMCID: PMC10922498, DOI: 10.1002/art.42738.Peer-Reviewed Original ResearchConceptsGiant cell arteritisClonal hematopoiesisHematologic malignanciesTET2 mutationsVision lossSomatic TET2 mutationsClinical phenotypes of giant cell arteritisDevelopment of giant cell arteritisGiant cell arteritis diagnosisAssociated with vision lossSomatic mutationsPresence of somatic mutationsIncident giant cell arteritisDevelopment of hematological malignanciesUKB participantsInfluence clinical outcomesMultivariate Cox regressionSomatic genetic testingPresence of mutationsElectronic health record reviewHealth record reviewUK Biobank (UKBGCA cohortClinical outcomesClonal mutations
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