Enhanced insights into the genetic architecture of 3D cranial vault shape using pleiotropy-informed GWAS
Goovaerts S, Naqvi S, Hoskens H, Herrick N, Yuan M, Shriver M, Shaffer J, Walsh S, Weinberg S, Wysocka J, Claes P. Enhanced insights into the genetic architecture of 3D cranial vault shape using pleiotropy-informed GWAS. Communications Biology 2025, 8: 439. PMID: 40087503, PMCID: PMC11909261, DOI: 10.1038/s42003-025-07875-6.Peer-Reviewed Original ResearchConceptsCranial vault shapeVault shapeGenomic lociGenetic discovery effortsSNP discoveryCraniofacial developmentGenetic architectureGWAS dataGWAS studiesTranscription factorsGenetic studiesCranial vaultGenetic understandingShape variationSignaling pathwayBrain shapeExperimental biologyBrain shape variationCraniofacial complexFDR methodLociDiscovery effortsFacial shapeWealth of knowledgeGWAS
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