2017
Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)
Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI. Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA). Nature Communications 2017, 8: 798. PMID: 28986525, PMCID: PMC5630596, DOI: 10.1038/s41467-017-01143-w.Peer-Reviewed Original ResearchConceptsMitochondrial metabolismHepatic mitochondrial metabolismPyruvate carboxylase fluxCitrate synthase fluxPyruvate cyclingMitochondrial uncouplerIntermediary metabolismSpectrometry analysisPhysiological conditionsChromatography-mass spectrometry analysisSynthase fluxCentral roleMetabolismHepatic mitochondriaGas chromatography-mass spectrometry analysisVivo NMR spectroscopyMitochondriaNMR spectroscopyRegulationUncouplerRoleTracer analysisVivoMaintenance of normoglycemiaWide range
1996
Hydroxyalkenal Formation Induced by Advanced Glycosylation of Low Density Lipoprotein (∗)
Al-Abed Y, Bucala R, Liebich H, Voelter W. Hydroxyalkenal Formation Induced by Advanced Glycosylation of Low Density Lipoprotein (∗). Journal Of Biological Chemistry 1996, 271: 2892-2896. PMID: 8621676, DOI: 10.1074/jbc.271.6.2892.Peer-Reviewed Original ResearchConceptsChemical ionization mass spectroscopyGas chromatography-mass spectrometry analysisIonization mass spectroscopyChromatography-mass spectrometry analysisOxidation product 4Acid side chainsUnsaturated fatty acyl groupsTransition metalsFatty acid side chainsHead groupsMass spectroscopySide chainsProduct 4Chemical basisCovalent additionFatty acyl groupsFree radical generating systemOxidationRadical generating systemSpectrometry analysisAcyl groupsMajor compoundsTissue LDL receptorsHigh affinityOxidative modification
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