2010
Evolution of peroxisome proliferator-activated receptor gamma alternative splicing.
Dou T, Xu J, Gao Y, Gu J, Ji C, Xie Y, Zhou Y. Evolution of peroxisome proliferator-activated receptor gamma alternative splicing. Frontiers In Bioscience-Elite 2010, 2: 1334-43. PMID: 20515805, DOI: 10.2741/e193.Peer-Reviewed Original ResearchConceptsKa/KsGamma geneHigher Ka/KsAlternative splicing exonsDifferent transcript variantsPPAR-gamma geneAdaptive evolutionVertebrate speciesAlternative splicingEvolutionary changeAlternative exonsEST dataGenomic sequencesNew exonsPeroxisome proliferator-activated receptor gammaTranscript variantsProliferator-activated receptor gammaConstitutive counterpartExonsGenesReceptor gammaGlucose homeostasisVertebratesImportant roleSplicing
2009
Complex developmental patterns of histone modifications associated with the human β-globin switch in primary cells
Hsu M, Richardson CA, Olivier E, Qiu C, Bouhassira EE, Lowrey CH, Fiering S. Complex developmental patterns of histone modifications associated with the human β-globin switch in primary cells. Experimental Hematology 2009, 37: 799-806.e4. PMID: 19460472, PMCID: PMC2748252, DOI: 10.1016/j.exphem.2009.04.006.Peer-Reviewed Original ResearchConceptsHistone modificationsGene expressionBeta-globin switchDimethyl lysine 9Beta-globin locusΒ-globin switchGamma geneImportant histone modificationsBone marrow cellsGamma gene expressionSuch histonesComplex developmental patternLysine 9Chromatin immunoprecipitationHistone H3Gene suppressionPrimary fetalMarrow cellsUnexpressed genesGamma-globinGenesHistonesDevelopmental stagesBone marrow erythroblastsPrimary cells
1995
α β and γ δ T cells can share a late common precursor
Dudley E, Girardi M, Owen M, Hayday A. α β and γ δ T cells can share a late common precursor. Current Biology 1995, 5: 659-669. PMID: 7552177, DOI: 10.1016/s0960-9822(95)00131-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCell DifferentiationDendritic CellsDNA NucleotidyltransferasesGene Rearrangement, T-LymphocyteHematopoiesisHematopoietic Stem CellsMiceMice, Inbred C57BLMolecular Sequence DataPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaStochastic ProcessesT-Lymphocyte SubsetsVDJ RecombinasesConceptsDelta geneSuccessful rearrangementLineage-determining factorsT cell receptorGene rearrangement processTCR-alpha gene rearrangementsAlpha gene rearrangementsTCR beta locusVertebrate developmentTCR delta geneAlpha betaSeparate lineagesTCR delta locusProductive rearrangementsDelta gene segmentsDelta locusBeta locusPolypeptide chainIndividual thymocytesGenesGamma geneT cell differentiationGene segmentsFragment length polymorphism techniqueCommon precursor
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