2023
IL-7R licenses a population of epigenetically poised memory CD8+ T cells with superior antitumor efficacy that are critical for melanoma memory
Micevic G, Daniels A, Flem-Karlsen K, Park K, Talty R, McGeary M, Mirza H, Blackburn H, Sefik E, Cheung J, Hornick N, Aizenbud L, Joshi N, Kluger H, Iwasaki A, Bosenberg M, Flavell R. IL-7R licenses a population of epigenetically poised memory CD8+ T cells with superior antitumor efficacy that are critical for melanoma memory. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2304319120. PMID: 37459511, PMCID: PMC10372654, DOI: 10.1073/pnas.2304319120.Peer-Reviewed Original ResearchConceptsIL-7R expressionT cellsIL-7RAntitumor memorySuperior antitumor efficacyCell-based therapiesTumor-specific T cellsAntigen-specific T cellsAntitumor efficacyPowerful antitumor immune responseMarkers of exhaustionTumor-specific CD8Antitumor immune responseIndependent prognostic factorAntitumor immune memoryMemory T cellsMajor risk factorSuperior antitumor activityFunctional CD8Memory CD8Prognostic factorsSurgical resectionAdvanced melanomaLymph nodesNaive mice
2016
The multifaceted role of CD4+ T cells in CD8+ T cell memory
Laidlaw BJ, Craft JE, Kaech SM. The multifaceted role of CD4+ T cells in CD8+ T cell memory. Nature Reviews Immunology 2016, 16: 102-111. PMID: 26781939, PMCID: PMC4860014, DOI: 10.1038/nri.2015.10.Peer-Reviewed Original ResearchConceptsT cell responsesT cell poolDendritic cellsT cell helpT cellsMemory CD8Cell helpCell responsesSuppression of DCTissue-resident memory CD8Regulatory T cellsT cell memoryCell poolSuppression of TNFApoptosis-inducing ligandEffector CD4Treg cellsFunctional CD8IL-21Primary CD8Protective immunityInterleukin-15Secondary responsivenessChronic infectionIL-2
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