2016
The multifaceted role of CD4+ T cells in CD8+ T cell memory
Laidlaw BJ, Craft JE, Kaech SM. The multifaceted role of CD4+ T cells in CD8+ T cell memory. Nature Reviews Immunology 2016, 16: 102-111. PMID: 26781939, PMCID: PMC4860014, DOI: 10.1038/nri.2015.10.Peer-Reviewed Original ResearchConceptsT cell responsesT cell poolDendritic cellsT cell helpT cellsMemory CD8Cell helpCell responsesSuppression of DCTissue-resident memory CD8Regulatory T cellsT cell memoryCell poolSuppression of TNFApoptosis-inducing ligandEffector CD4Treg cellsFunctional CD8IL-21Primary CD8Protective immunityInterleukin-15Secondary responsivenessChronic infectionIL-2
2002
Strength of prior stimuli determines the magnitude of secondary responsiveness in CD8+ T cells
Lim DG, Höllsberg P, Hafler DA. Strength of prior stimuli determines the magnitude of secondary responsiveness in CD8+ T cells. Cellular Immunology 2002, 217: 36-46. PMID: 12425999, DOI: 10.1016/s0008-8749(02)00511-7.Peer-Reviewed Original ResearchConceptsT cellsSecondary responsivenessCostimulatory moleculesInduction of CD8Magnitude of CD8T cell responsesT cell anergyCell anergyCD8Prior stimulusSecondary stimulationPrimary stimulationCell responsesCellular mechanismsFollowing activationPeptide ligandsActivation thresholdStimulationCellsResponsivenessHigh levelsCD4AnergyStimuliStrength of signal
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