2025
Does gonadotoxic chemotherapy deplete the ovarian reserve through activation of primordial follicles?
Erden M, Oktay K. Does gonadotoxic chemotherapy deplete the ovarian reserve through activation of primordial follicles? Human Reproduction 2025, 40: 571-579. PMID: 39986689, DOI: 10.1093/humrep/deaf024.Peer-Reviewed Original ResearchPrimordial follicle activationFollicle activationGonadotoxic chemotherapyOvarian reserveOvarian primordial follicle reserveActivation of primordial folliclesOvarian reserve depletionPrimordial follicle depletionPrimordial follicle reserveChemotherapy-induced damageFollicle reservePrimordial folliclesChemotherapy exposureFollicle depletionFollicle deathFertility preservationPharmacological optionsChemotherapyApoptotic deathBradford Hill criteriaDNA double-strand breaksFolliclesMolecular mechanismsDouble-strand breaksDeath
2024
P-587 Salidroside improves the reproductive capacity of aged mice via improving oocyte mitochondrial function
Gu J, Hua R, Guo C, Hai Z, Xiao Y, Zhao P, Li Y, Su J, Wang T. P-587 Salidroside improves the reproductive capacity of aged mice via improving oocyte mitochondrial function. Human Reproduction 2024, 39: deae108.919. DOI: 10.1093/humrep/deae108.919.Peer-Reviewed Original ResearchOvarian agingIVM treatment groupsGV oocytesFemale miceTreatment groupsAged miceDays of in vivo treatmentOocyte mitochondrial functionIn vivoOvarian reserve functionIn vitroTreatment of ovarian agingFunction of miceMitochondrial functionFollicle reserveMII oocytesTherapeutic effect of salidrosideAged oocytesParthenogenetic activationC57/B6 miceOocyte qualityMaternal ageParthenogenetic embryosWider implicationsSalidroside supplementation
2022
Female Infertility
Oktay K, Taylan E. Female Infertility. 2022, 1376-1381. DOI: 10.1093/med/9780198870197.003.0165.Peer-Reviewed Original ResearchFertility preservationOvarian insufficiencyOvarian follicle reservePreservation of fertilityReproductive-age womenEffective treatment optionOvarian endocrine functionAntineoplastic treatmentSurgical interventionFollicle reserveTreatment optionsAge womenFemale infertilityEndocrine functionPsychosocial healthChromosomal disordersReproductive technologiesWomenImproved qualityModern healthcareIrreversible lossInfertilityInsufficiency
2021
Individual-oocyte transcriptomic analysis shows that genotoxic chemotherapy depletes human primordial follicle reserve in vivo by triggering proapoptotic pathways without growth activation
Titus S, Szymanska K, Musul B, Turan V, Taylan E, Garcia- Milian R, Mehta S, Oktay K. Individual-oocyte transcriptomic analysis shows that genotoxic chemotherapy depletes human primordial follicle reserve in vivo by triggering proapoptotic pathways without growth activation. Scientific Reports 2021, 11: 407. PMID: 33431979, PMCID: PMC7801500, DOI: 10.1038/s41598-020-79643-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntineoplastic Combined Chemotherapy ProtocolsApoptosisCyclophosphamideDNA DamageFemaleGene Expression ProfilingHeterograftsHumansMiceMice, Inbred NODMice, SCIDOocytesOogenesisOvarian FollicleOvarian ReserveOvarySignal TransductionSingle-Cell AnalysisTranscriptomeYoung AdultConceptsPrimordial follicle oocytesFollicle lossGrowth activationHuman ovarian xenograft modelPI3K/PTEN/AktFollicle oocytesDNA damagePI3K/PTEN/Akt pathwayOvarian reserve depletionPrimordial follicle reservePTEN/AKT pathwayIngenuity Pathway AnalysisOvarian xenograft modelPTEN/AKTSevere DNA damageExpression of AktGonadotoxic chemotherapyAnti-apoptotic Bcl2Early menopauseFollicle reserveTranscriptomic analysisCyclophosphamide injectionHuman ovaryPhosphorylation statusRNA sequencing
2020
Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging
Szymanska K, Tan X, Oktay K. Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging. Molecular Human Reproduction 2020, 26: 553-566. PMID: 32514568, PMCID: PMC7411370, DOI: 10.1093/molehr/gaaa043.Peer-Reviewed Original ResearchConceptsPrimordial follicle reserveChemotherapy-induced damageFollicle reserveOvarian reserveChemotherapy-induced lossOvarian reserve depletionApoptotic deathPrimordial follicle oocytesFertility preservationAcute reductionOvarian agingHuman ovaryFollicle activationPrimordial folliclesAcute exposureStromal damageTranslational evidenceChemotherapeutic agentsApoptotic lossFollicle oocytesDNA double-strand breaksDNA DSBsCurrent literatureDeathActivation
2006
O-223 A novel ovarian xenografting model to characterize the impact of chemotherapy agents on human primordial follicle reserve
Oktay K, Oktem O. O-223 A novel ovarian xenografting model to characterize the impact of chemotherapy agents on human primordial follicle reserve. Fertility And Sterility 2006, 86: s95-s96. DOI: 10.1016/j.fertnstert.2006.07.255.Peer-Reviewed Original ResearchP-477 Histological quantification of the impact of chemotherapy on human primordial follicle reserve in women
Oktem O, Oktay K. P-477 Histological quantification of the impact of chemotherapy on human primordial follicle reserve in women. Fertility And Sterility 2006, 86: s312-s313. DOI: 10.1016/j.fertnstert.2006.07.840.Peer-Reviewed Original Research
2000
New Strategies in Studying Ovarian Aging
Oktay K, Karlikaya G, Bayrakceken A. New Strategies in Studying Ovarian Aging. Serono Symposia USA 2000, 80-88. DOI: 10.1007/978-0-387-21628-7_8.Peer-Reviewed Original Research
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