2018
Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver
Kalvisa A, Siersbæk M, Præstholm S, Christensen L, Nielsen R, Stohr O, Vettorazzi S, Tuckermann J, White M, Mandrup S, Grøntved L. Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver. PLOS Biology 2018, 16: e2006249. PMID: 30532187, PMCID: PMC6301715, DOI: 10.1371/journal.pbio.2006249.Peer-Reviewed Original ResearchConceptsCircadian gene transcriptionGene transcriptionGene expressionCircadian-regulated genesInsulin-regulated genesGenomic approachesGlucocorticoid receptorGene programEnhancer activityCistromic analysisGlucocorticoid receptor activityGenesMechanistic insightsTranscriptionFeeding behaviorSelective disruptionDiet-induced obese animalsEnhancerReceptor activityFeeding responseDiet-induced obesityExpressionDysregulationChromatinFOXO1
1999
Interactions between Neuropeptide Y and γ -Aminobutyric Acid in Stimulation of Feeding: A Morphological and Pharmacological Analysis*
Pu S, Jain M, Horvath T, Diano S, Kalra P, Kalra S. Interactions between Neuropeptide Y and γ -Aminobutyric Acid in Stimulation of Feeding: A Morphological and Pharmacological Analysis*. Endocrinology 1999, 140: 933-940. DOI: 10.1210/en.140.2.933.Peer-Reviewed Original ResearchParaventricular nucleusStimulation of feedingNeuropeptide YG-aminobutyric acidFood intakeArcuate nucleusCoadministration of neuropeptide YNPY-induced food intakeSite of NPY actionEffects of muscimolGABAA receptor agonistDose-related fashionSubpopulations of NPY neuronsElectron microscopic double stainingRat brain sectionsFeeding responseSated ratsNPY neuronsReceptor agonistsNPY actionMessenger systemsMuscimolHypothalamic controlBrain stemGABAInteractions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis.
Pu S, Jain M, Horvath T, Diano S, Kalra P, Kalra S. Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis. Endocrinology 1999, 140: 933-40. PMID: 9927326, DOI: 10.1210/endo.140.2.6495.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidStimulation of feedingNeuropeptide YParaventricular nucleusFood intakeArcuate nucleusDose-related fashionEffects of muscimolFeeding responseRat brain sectionsNPY actionNPY terminalsNPY neuronsBrain stemHypothalamic controlReceptor agonistSecond messenger systemsSated ratsAxon terminalsBrain sectionsMagnocellular divisionMuscimolMorphological findingsPharmacological analysisDistinct receptors
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