In utero human intestine contains maternally derived bacterial metabolites
Wang W, Gu W, Schweitzer R, Koren O, Khatib S, Tseng G, Konnikova L. In utero human intestine contains maternally derived bacterial metabolites. Microbiome 2025, 13: 116. PMID: 40329366, PMCID: PMC12054239, DOI: 10.1186/s40168-025-02110-0.Peer-Reviewed Original ResearchConceptsImmune systemFetal intestineAryl hydrocarbon receptorFetal immune systemMucosal immune regulationIntestinal immune systemIntestinal metabolomic profilesIntestinal tissueSecondary bile acidsHuman intestinal tissueMaternal deciduaFetal meconiumPlacental villiMicrobial metabolitesPlacental tissueMetabolomic profilesDecidua samplesMeconium samplesImmune regulationAdaptive immunityMicrobial encountersGastrointestinal tractShort-chain fatty acidsDisease prevention strategiesMeconium
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