2025
Disruptions in Reward-Guided Decision-Making Functions Are Predictive of Greater Oral Oxycodone Self-Administration in Male and Female Rats
LaRocco K, Villiamma P, Hill J, Russell M, DiLeone R, Groman S. Disruptions in Reward-Guided Decision-Making Functions Are Predictive of Greater Oral Oxycodone Self-Administration in Male and Female Rats. Biological Psychiatry Global Open Science 2025, 5: 100450. PMID: 40083740, PMCID: PMC11904576, DOI: 10.1016/j.bpsgos.2025.100450.Peer-Reviewed Original ResearchAddiction-relevant behaviorsBiobehavioral mechanismsReward-guided decision-makingProbabilistic reversal-learning taskSaccharin fading procedureOxycodone self-administrationFemale Long-Evans ratsReversal-learning taskPathology of addictionFemale ratsTest of motivationDrug useLong-Evans ratsSuboptimal decision-makingOpioid use disorderSelf-AdministrationAddiction susceptibilityFading procedureEvans ratsSex differencesProblematic opioid useAdaptive decision-making processesDecision-making functionsAddictionDecision-making data
2023
Nucleus accumbens and dorsal medial striatal dopamine and neural activity are essential for action sequence performance
Fraser K, Chen B, Janak P. Nucleus accumbens and dorsal medial striatal dopamine and neural activity are essential for action sequence performance. European Journal Of Neuroscience 2023, 59: 220-237. PMID: 38093522, PMCID: PMC10841748, DOI: 10.1111/ejn.16210.Peer-Reviewed Original ResearchNucleus accumbens coreDorsomedial striatumDopamine transmissionNeural activityFemale Long-Evans ratsLong-Evans ratsSequence performanceStriatal dopamineDopamine antagonistsDopamine antagonismNucleus accumbensStriatal circuitsDopamine systemDorsolateral striatumPharmacological inactivationAbsence of cuesAccumbens coreNumber of rewardsDistinct leversFlupenthixolInstrumental behaviorStriatumTask variationAction chainsAction sequences
2022
Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats
Villiamma P, Casby J, Groman SM. Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats. Psychopharmacology 2022, 239: 2885-2901. PMID: 35705734, PMCID: PMC10332493, DOI: 10.1007/s00213-022-06174-w.Peer-Reviewed Original ResearchConceptsCocaine-taking behaviorReversal-learning performanceDecision-making functionsReversal-learning taskReinforcement learning modelIndividual differencesAdolescent developmentFemale Long-Evans ratsRewarded outcomesDevelopmental trajectoriesNeurobiological mechanismsAdolescent trajectoriesAge-related changesGreater cocaineBiobehavioral mechanismsNeural adaptationLong-Evans ratsPredictive relationshipAddiction susceptibilityAdolescenceChoice behaviorAdulthoodDecision-making trajectoriesMental illnessChoice data
2020
Reinforcement Learning during Adolescence in Rats
Afshar N, Keip AJ, Taylor JR, Lee D, Groman SM. Reinforcement Learning during Adolescence in Rats. Journal Of Neuroscience 2020, 40: 5857-5870. PMID: 32601244, PMCID: PMC7380962, DOI: 10.1523/jneurosci.0910-20.2020.Peer-Reviewed Original ResearchConceptsNovel behavioral protocolReversal-learning performanceAdaptive choice behaviorBehavioral protocolFemale Long-Evans ratsReversal performanceChoice behaviorLong-Evans ratsAdolescent brain functionAge-related improvementsReinforcement-learning mechanismsReversal-learning taskReversal-learning paradigmDecision-making paradigmReinforcement learning mechanismAdolescent ratsLongitudinal designAge-related changesNeurodevelopmental mechanismsAdolescencePositive outcomesBrain functionFunction of circuitsPostnatal day 30AdulthoodPotential Neurodevelopmental Effects of Pediatric Intensive Care Sedation and Analgesia: Repetitive Benzodiazepine and Opioid Exposure Alters Expression of Glial and Synaptic Proteins in Juvenile Rats
Iqbal O'Meara AM, Miller Ferguson N, Zven SE, Karam OL, Meyer LC, Bigbee JW, Sato-Bigbee C. Potential Neurodevelopmental Effects of Pediatric Intensive Care Sedation and Analgesia: Repetitive Benzodiazepine and Opioid Exposure Alters Expression of Glial and Synaptic Proteins in Juvenile Rats. Critical Care Explorations 2020, 2: e0105. PMID: 32426747, PMCID: PMC7188419, DOI: 10.1097/cce.0000000000000105.Peer-Reviewed Original ResearchS100 calcium-binding protein BCalcium-binding protein BGlial fibrillary acidic proteinFibrillary acidic proteinCalcium-binding adaptor molecule 1Adaptor molecule 1Acidic proteinMyelin basic proteinMorphine animalsNeurodevelopmental effectsMolecule-1Intensive care sedationInjection of morphinePotential neurodevelopmental effectsFemale Long-Evans ratsPostnatal day 23Postnatal day 18Novel rodent modelLong-Evans ratsBasic science laboratoryProtein BBasic proteinPICU patientsNeurologic dysfunctionMidazolam administration
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