Disruptions in Reward-Guided Decision-Making Functions Are Predictive of Greater Oral Oxycodone Self-Administration in Male and Female Rats
LaRocco K, Villiamma P, Hill J, Russell M, DiLeone R, Groman S. Disruptions in Reward-Guided Decision-Making Functions Are Predictive of Greater Oral Oxycodone Self-Administration in Male and Female Rats. Biological Psychiatry Global Open Science 2025, 5: 100450. PMID: 40083740, PMCID: PMC11904576, DOI: 10.1016/j.bpsgos.2025.100450.Peer-Reviewed Original ResearchAddiction-relevant behaviorsBiobehavioral mechanismsReward-guided decision-makingProbabilistic reversal-learning taskSaccharin fading procedureOxycodone self-administrationFemale Long-Evans ratsReversal-learning taskPathology of addictionFemale ratsTest of motivationDrug useLong-Evans ratsSuboptimal decision-makingOpioid use disorderSelf-AdministrationAddiction susceptibilityFading procedureEvans ratsSex differencesProblematic opioid useAdaptive decision-making processesDecision-making functionsAddictionDecision-making data
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