2023
Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production
Song J, Lv H, Liu B, Hao M, Taylor H, Zhang X, Li D, Huang Y. Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production. Molecular Metabolism 2023, 78: 101828. PMID: 37898449, PMCID: PMC10641683, DOI: 10.1016/j.molmet.2023.101828.Peer-Reviewed Original ResearchConceptsFas-mediated apoptosisLet-7Hepatocyte apoptosisNegative feedback loopMouse primary hepatocytesLet-7 miRNAsTGF-b signalingSignaling networksApoptosis of hepatocytesTransient transfectionFAS expressionInhibiting hepatocyte apoptosisSiRNA knockdownLet-7 expressionLet-7 overexpressionMouse modelApoptosisPrimary hepatocytesSuppressed hepatocyte apoptosisTET3Liver fibrosisFeedback loopExpressionDriver of liver fibrosisAdeno-associated viral vectors
2002
Alterations of Fas-pathway genes associated with nodal metastasis innon-small cell lung cancer
Shin M, Kim H, Lee S, Lee J, Song Y, Kim Y, Park W, Kim S, Lee S, Park J, Lee J, Xiao W, Jo K, Wang Y, Lee K, Park Y, Kim S, Lee J, Yoo N. Alterations of Fas-pathway genes associated with nodal metastasis innon-small cell lung cancer. Oncogene 2002, 21: 4129-4136. PMID: 12037669, DOI: 10.1038/sj.onc.1205527.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAllelesApoptosisBase SequenceCarcinoma, Non-Small-Cell LungCarrier ProteinsCaspase 10Caspase 8Caspase 9CaspasesDNA Primersfas ReceptorFas-Associated Death Domain ProteinHumansLoss of HeterozygosityLung NeoplasmsLymphatic MetastasisMutagenesis, Site-DirectedConceptsFas-mediated apoptosisPathways of Fas-mediated apoptosisNon-small cell lung cancerResistance to Fas-mediated apoptosisTumor-derived mutantsProximal pathwayCancer cell deathApoptosis inductionWild typeInactivating mutationsTransfection studiesCell deathMetastasis of non-small cell lung cancerSomatic mutationsGenesCell lung cancerMutationsRegional lymph nodesApoptosisCancer cellsCancer metastasisMetastasis lesionsPrimary lesionLymph nodesLung cancer
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