2009
Dynamics of α-globin locus chromatin structure and gene expression during erythroid differentiation of human CD34+ cells in culture
Mahajan MC, Karmakar S, Newburger PE, Krause DS, Weissman SM. Dynamics of α-globin locus chromatin structure and gene expression during erythroid differentiation of human CD34+ cells in culture. Experimental Hematology 2009, 37: 1143-1156.e3. PMID: 19607874, PMCID: PMC2997688, DOI: 10.1016/j.exphem.2009.07.001.Peer-Reviewed Original ResearchMeSH Keywordsalpha-GlobinsAntigens, CD34CCCTC-Binding FactorCells, CulturedChromatin Assembly and DisassemblyEnhancer Elements, GeneticErythroid Precursor CellsErythropoiesisErythropoietinGATA1 Transcription FactorGene Expression Regulation, DevelopmentalGlycophorinsHematopoietic Cell Growth FactorsHistonesHumansInsulator ElementsNF-E2 Transcription Factor, p45 SubunitProtein BindingRepressor ProteinsRNA Polymerase IITranscription FactorsConceptsAlpha-globin lociTranscription factor recruitmentChromatin structureGATA-1Transcription factorsErythroid differentiationGene expressionFactor recruitmentPol IIQuantitative polymerase chain reaction analysisAlpha-globin gene expressionKey erythroid transcription factorsErythroid transcription factorsNF-E2Chromatin immunoprecipitation-quantitative polymerase chain reaction analysisAlpha-globin genesUpstream activator sitesBeta-like genesPolymerase chain reaction analysisChain reaction analysisStages of erythropoiesisGlobin promoterDifferent differentiation stagesFactor CTCFHistone modifications
2001
Loss of imprinting of insulin-like growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site.
Cui H, Niemitz EL, Ravenel JD, Onyango P, Brandenburg SA, Lobanenkov VV, Feinberg AP. Loss of imprinting of insulin-like growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site. Cancer Research 2001, 61: 4947-50. PMID: 11431321.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBase SequenceBinding SitesCCCTC-Binding FactorDNA MethylationDNA-Binding ProteinsGene Expression Regulation, NeoplasticGenomic ImprintingHumansInsulin-Like Growth Factor IIMutationRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionRNA, Long NoncodingRNA, MessengerRNA, UntranslatedTranscription FactorsWilms TumorConceptsLoss of imprintingH19 DMRMaternal alleleActive maternal alleleAberrant methylationTranscription factor CTCFInsulin-like growth factor II geneSilent maternal alleleGrowth factor II geneFactor II geneFactor CTCFTranscriptional silencingConsensus sitesCTCF geneNormal imprintingH19 geneCTCFIGF2 imprintingMaternal copyWilms tumorRegion upstreamCommon molecular abnormalityMethylationInsulin-like growth factor IIGenes
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