Inhibition of MIF with an Allosteric Inhibitor Triggers Cell Cycle Arrest in Acute Myeloid Leukemia
Pantouris G, Khurana L, Tilstam P, Benner A, Cho T, Lelaidier M, Perrée M, Rosenbaum Z, Leng L, Foss F, Bhandari V, Verma A, Bucala R, Lolis E. Inhibition of MIF with an Allosteric Inhibitor Triggers Cell Cycle Arrest in Acute Myeloid Leukemia. ACS Omega 2025, 10: 17441-17452. PMID: 40352549, PMCID: PMC12059935, DOI: 10.1021/acsomega.4c10969.Peer-Reviewed Original ResearchAcute myeloid leukemiaMacrophage migration inhibitory factorCell cycle arrestNational Cancer InstituteMyeloid leukemiaMicroenvironment of acute myeloid leukemiaMIF receptorMultiple AML cell linesCycle arrestAcute myeloid leukemia pathogenesisInhibition of macrophage migration inhibitory factorPromote tumor cell survivalAcute myeloid leukemia cell survivalAcute myeloid leukemia cellsCell survivalCell linesAcute myeloid leukemia cell line HL-60Triggered cell cycle arrestTumor cell survivalAML cell linesMigration inhibitory factorMIF inhibitorExtract mechanistic insightsG0/G1 cell cycle arrestProliferation of AML cells
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