Intrahepatic Cholangiocarcinomas Have Histologically and Immunophenotypically Distinct Small and Large Duct Patterns
Sigel C, Drill E, Zhou Y, Basturk O, Askan G, Pak L, Vakiani E, Wang T, Boerner T, Do R, Simpson A, Jarnagin W, Klimstra D. Intrahepatic Cholangiocarcinomas Have Histologically and Immunophenotypically Distinct Small and Large Duct Patterns. The American Journal Of Surgical Pathology 2018, 42: 1334-1345. PMID: 30001234, PMCID: PMC6657522, DOI: 10.1097/pas.0000000000001118.Peer-Reviewed Original ResearchMeSH KeywordsAgedBile Duct NeoplasmsBile Ducts, IntrahepaticBiomarkers, TumorBiopsyCholangiocarcinomaDatabases, FactualFemaleHumansImmunohistochemistryImmunophenotypingIn Situ HybridizationMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPhenotypeProgression-Free SurvivalRetrospective StudiesConceptsPT stageIntrahepatic cholangiocarcinomaSmall ductsAssociated with mucin productionCA19-9 stainingRecurrence-free survivalResected intrahepatic cholangiocarcinomaPrimary sclerosing cholangitisAssociated with subtypesRNA in situ hybridizationPositive tumorsPerineural invasionPeriductal infiltrationHistological typeFrequent alcohol useSclerosing cholangitisImmunophenotypic characteristicsS100P expressionExtracellular mucinChronic hepatitisHistologic associationDuct patternMultivariate analysisRisk factorsMucin production
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