GIRK currents in VTA dopamine neurons control the sensitivity of mice to cocaine-induced locomotor sensitization
Rifkin R, Huyghe D, Li X, Parakala M, Aisenberg E, Moss S, Slesinger P. GIRK currents in VTA dopamine neurons control the sensitivity of mice to cocaine-induced locomotor sensitization. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e9479-e9488. PMID: 30228121, PMCID: PMC6176583, DOI: 10.1073/pnas.1807788115.Peer-Reviewed Original ResearchConceptsVentral tegmental areaVentral tegmental area dopamine neuronsCocaine-induced locomotor sensitizationDopamine neuronsLocomotor sensitizationVTA dopamine neuronsSubstantia nigra pars compactaGIRK currentsG-protein-gated inwardly rectifying potassium channelsCocaine addictionReward circuitTegmental areaGIRK channelsEndosomal adaptor proteinTreat addictionGIRK3 subunitsNeural circuitsInwardly rectifying potassium channelsRectifying potassium channelsDopamineGABAAddictionSpike firingSource of inhibitionGIRK
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