2025
Impact of peritoneal macrophage depletion on endometriotic lesion development in a mouse model
Stratopoulou C, Cacciottola L, Gawde N, Ngombo A, Brusa D, Donnez J, Taylor H, Dolmans M. Impact of peritoneal macrophage depletion on endometriotic lesion development in a mouse model. Journal Of Endometriosis And Uterine Disorders 2025, 10: 100113. DOI: 10.1016/j.jeud.2025.100113.Peer-Reviewed Original ResearchMacrophage depletionEndometriotic lesionsTreated miceMacrophage accumulationMouse modelVascular endothelial growth factor immunostainingEndometriosis developmentQuantification of immune cellsFlow cytometryMouse model of endometriosisClodronate-containing liposomesKi67-positive proliferating cellsNovel therapeutic optionsRate of fibrosisModel of endometriosisTUNEL-positive apoptotic cellsLevels of fibrosisPathogenesis of endometriosisReproductive-age womenMasson's trichrome stainingEndometriotic lesion developmentEnhanced cell deathPlacebo-ControlledUterine fragmentsT cells
2023
Donor Mesenchymal Stem Cells Program Bone Marrow, Altering Macrophages, and Suppressing Endometriosis in Mice
Habata S, Mamillapalli R, Ucar A, Taylor H. Donor Mesenchymal Stem Cells Program Bone Marrow, Altering Macrophages, and Suppressing Endometriosis in Mice. Stem Cells International 2023, 2023: 1598127. PMID: 37545483, PMCID: PMC10403325, DOI: 10.1155/2023/1598127.Peer-Reviewed Original ResearchBone marrowMesenchymal stem cellsBM transplantsEndometriotic lesionsM2 macrophagesBone marrow-derived inflammatory cellsTumor necrosis factor alphaImmune system contributionsDonor mesenchymal stem cellsProportion of M1Infiltration of macrophagesDevelopment of endometriosisNecrosis factor alphaNew therapeutic targetsRecipient bone marrowReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionEndometriotic lesion developmentInflammatory markersEndometrial tissueInflammatory cellsRecipient micePolymerase chain reactionInflammatory responseFluorescence-activated cell sorting
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