2021
Effect of Mavacamten on Echocardiographic Features in Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy
Hegde SM, Lester SJ, Solomon SD, Michels M, Elliott PM, Nagueh SF, Choudhury L, Zemanek D, Zwas DR, Jacoby D, Wang A, Ho CY, Li W, Sehnert AJ, Olivotto I, Abraham TP. Effect of Mavacamten on Echocardiographic Features in Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy. Journal Of The American College Of Cardiology 2021, 78: 2518-2532. PMID: 34915982, DOI: 10.1016/j.jacc.2021.09.1381.Peer-Reviewed Original ResearchConceptsObstructive hypertrophic cardiomyopathySystolic anterior motionAnterior motionDiastolic functionHypertrophic cardiomyopathyN-terminal pro-B-type natriuretic peptideMitral valve systolic anterior motionPro-B-type natriuretic peptidePeak exercise oxygen consumptionLeft ventricular diastolic functionVentricular outflow tract obstructionKey echocardiographic parametersAtrial volume indexOutflow tract obstructionVentricular diastolic functionExercise oxygen consumptionEffect of mavacamtenMyocardial wall stressEXPLORER-HCMLVOT gradientEchocardiographic featuresEchocardiographic parametersLVOT obstructionTract obstructionExercise capacity
2014
Prognostic Implications of Initial Echocardiographic Findings in Adolescents and Adults with Supracristal Ventricular Septal Defects
Cho M, Jang S, Sun B, Jang J, Ahn J, Kim D, Song J, Kang D, Song J. Prognostic Implications of Initial Echocardiographic Findings in Adolescents and Adults with Supracristal Ventricular Septal Defects. Journal Of The American Society Of Echocardiography 2014, 27: 965-971. PMID: 24996557, DOI: 10.1016/j.echo.2014.05.016.Peer-Reviewed Original ResearchConceptsSupracristal ventricular septal defectVentricular septal defectOverall survival rateAortic regurgitationGroup 1Septal defectSurvival rateValsalva ruptureGroup 2High-risk echocardiographic featuresProgression-free survival ratesPerimembranous ventricular septal defectEvent-free rateInitial echocardiographic findingsSevere aortic regurgitationRetrospective observational studySinus of ValsalvaMain clinical eventsAR progressionEchocardiographic featuresEchocardiographic findingsHeart failurePediatric patientsPrognostic implicationsClinical events
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