Inactivating mutations of caspase-8 gene in colorectal carcinomas
Kim H, Lee J, Soung Y, Park W, Kim S, Lee J, Park J, Cho Y, Kim C, Jeong S, Nam S, Kim S, Lee J, Yoo N, Lee S. Inactivating mutations of caspase-8 gene in colorectal carcinomas. Gastroenterology 2003, 125: 708-715. PMID: 12949717, DOI: 10.1016/s0016-5085(03)01059-x.Peer-Reviewed Original ResearchConceptsCaspase-8 geneCaspase-8 mutationCaspase-8Death receptor-induced apoptosisActivation of caspase-8Apoptosis activationInactivating mutationsSingle-strand conformation polymorphismSomatic mutationsReceptor-induced apoptosisDetection of somatic mutationsDysregulation of apoptosisDominant-negative inhibitionInitiator caspasesCaspase cascadeApoptotic functionColorectal carcinomaDNA sequencesCoding regionConformation polymorphismNonsense mutationMissense mutationsPathogenesis of cancer developmentLate stages of colorectal carcinogenesisMutantsMutational analysis of Noxa gene in human cancers
LEE S, SOUNG Y, LEE J, KIM H, LEE J, KIM H, LEE J, PARK J, CHO Y, KIM C, KIM S, PARK W, KIM S, LEE J, YOO N. Mutational analysis of Noxa gene in human cancers. Apmis 2003, 111: 599-604. PMID: 12969015, DOI: 10.1034/j.1600-0463.2003.1110602.x.Peer-Reviewed Original ResearchConceptsSingle strand conformation polymorphismNoxa geneSomatic mutationsBcl-2 homology 3 (BH3)-only memberHuman cancersAnti-apoptotic Bcl-2 family membersBcl-2Bcl-2 family membersMutation analysisBcl-2 familyDetection of somatic mutationsStrand conformation polymorphismDysregulation of apoptosisApoptosis-related genesCell death mechanismsPolymerase chain reactionPathogenesis of human cancersTransitional cell carcinomaMechanisms of cancer developmentSplice siteDNA sequencesCoding regionConformation polymorphismNoxaDeath mechanisms
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