2025
Transient Upregulation of Procaspase-3 during Oligodendrocyte Fate Decisions
Kamen Y, Chapman T, Piedra E, Ciolkowski M, Hill R. Transient Upregulation of Procaspase-3 during Oligodendrocyte Fate Decisions. Journal Of Neuroscience 2025, 45: e2066242025. PMID: 39837665, PMCID: PMC11924999, DOI: 10.1523/jneurosci.2066-24.2025.Peer-Reviewed Original ResearchProcaspase-3Fate decisionsOligodendrocyte precursor cellsCell death mechanismsNeurodegenerative conditionsOligodendrocyte differentiationSurvival decisionsCellular checkpointsDeath mechanismsMolecular markersPrecursor cellsOligodendrocyte markersPromote oligodendrocyte differentiationPharmacological inhibitionDifferentiation stageTransient upregulationDifferentiationZymogenCellsOligodendrocyte densityMorphological stateMale miceOligodendrocyte deathMyelin dysfunctionMarkers
2024
Oligodendrocyte Maturation Alters the Cell Death Mechanisms That Cause Demyelination
Chapman T, Kamen Y, Piedra E, Hill R. Oligodendrocyte Maturation Alters the Cell Death Mechanisms That Cause Demyelination. Journal Of Neuroscience 2024, 44: e1794232024. PMID: 38395617, PMCID: PMC10977033, DOI: 10.1523/jneurosci.1794-23.2024.Peer-Reviewed Original ResearchPoly-ADP-riboseCell deathSubcellular localizationCaspase-3-independent mechanismCombination of intravital imagingCaspase-3-dependent mechanismDNA damageMechanism of cell deathProgrammed Cell DeathPrevent cell deathCell death mechanismsExecutioner caspasesDelayed cell deathOligodendrocyte maturationCaspase-3Mature oligodendrocytesOligodendrocyte deathDeath mechanismsHuman diseasesHallmarks of diseaseMolecular mechanismsIndividual cellsMechanisms of oligodendrocyte deathIntravital imagingSingle-cell ablation
2020
Caspase 8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic induced necroptosis
Uzunparmak B, Gao M, Lindemann A, Erikson K, Wang L, Lin E, Frank SJ, Gleber-Netto FO, Zhao M, Skinner HD, Newton JM, Sikora AG, Myers JN, Pickering CR. Caspase 8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic induced necroptosis. JCI Insight 2020, 5: e139837. PMID: 33108350, PMCID: PMC7714407, DOI: 10.1172/jci.insight.139837.Peer-Reviewed Original ResearchConceptsReceptor-interacting serine/threonine-protein kinase 3Caspase-8Serine/threonine-protein kinase 3Regulated cell death mechanismsPan-caspase inhibitor z-VADSecond mitochondria-derived activatorProtein kinase 3Cell death mechanismsRIP3 functionSmac mimeticsZ-VADKinase 3Death mechanismsMolecular underpinningsNecroptosis pathwayHNSCC cell linesNecroptosisRIP3 expressionCancer cellsCell linesBirinapantNeck squamous cell carcinomaCASP8 mutationsSquamous cell carcinomaSyngeneic mouse model
2019
The role of necroptosis in cancer biology and therapy
Gong Y, Fan Z, Luo G, Yang C, Huang Q, Fan K, Cheng H, Jin K, Ni Q, Yu X, Liu C. The role of necroptosis in cancer biology and therapy. Molecular Cancer 2019, 18: 100. PMID: 31122251, PMCID: PMC6532150, DOI: 10.1186/s12943-019-1029-8.Peer-Reviewed Original ResearchConceptsMixed lineage kinase domain-likeReceptor-interacting protein 1Apoptosis resistanceNecrotic cell death modalitiesCell deathMode of programmed cell deathCaspase-independent fashionCancer metastasisTumor progressionLineage kinase domain-likeCancer cellsInduce cancer cell deathCell death modalitiesCell death mechanismsCancer cell deathCancer immunity regulationImmunosuppressive tumor microenvironmentPrognosis of cancer patientsApoptotic pathwayAdaptive immune responsesDeath modalitiesPromote oncogenesisNecroptotic pathwayDeath mechanismsMetabolic signals
2018
Cell Death in the Lung: The Apoptosis–Necroptosis Axis
Sauler M, Bazan IS, Lee PJ. Cell Death in the Lung: The Apoptosis–Necroptosis Axis. Annual Review Of Physiology 2018, 81: 1-28. PMID: 30485762, PMCID: PMC6598441, DOI: 10.1146/annurev-physiol-020518-114320.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRegulated cell deathCell deathAutophagic cell deathCell death mechanismsSuperfluous cellsAcute respiratory distress syndromeChronic obstructive pulmonary diseasePulmonary arterial hypertensionIdiopathic pulmonary fibrosisObstructive pulmonary diseaseRespiratory distress syndromeDeath mechanismsCellular mechanismsArterial hypertensionDistress syndromePulmonary diseasePulmonary fibrosisPulmonary disordersMajor mechanismDeathNew modalityPathogenesisNecroptosisMechanismApoptosis
2017
Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis
Zille M, Karuppagounder SS, Chen Y, Gough PJ, Bertin J, Finger J, Milner TA, Jonas EA, Ratan RR. Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis. Stroke 2017, 48: 1033-1043. PMID: 28250197, PMCID: PMC5613764, DOI: 10.1161/strokeaha.116.015609.Peer-Reviewed Original ResearchConceptsCell death mechanismsCaspase-dependent apoptosisDeath mechanismsMolecular markersChemical inhibitorsCell death pathwaysNecroptotic cell deathSecondary injuryNecroptotic signalingDeath pathwaysNecrotic phenotypeIntracerebral hemorrhageCell deathMRNA synthesisNecroptosisIntracerebral hemorrhage (ICH) resultsShare featuresFerroptosisHemin-induced toxicityFerroptosis inhibitorsAutophagyCultured neuronsApoptosisHemorrhage resultsNeuronal necrosis
2013
Molecular Basis of Cell Death Programs in Mature T Cell Homeostasis
Lucas C, Lenardo M. Molecular Basis of Cell Death Programs in Mature T Cell Homeostasis. 2013, 41-59. DOI: 10.1007/978-1-4614-9302-0_3.Peer-Reviewed Original ResearchPathological immune reactionsNumber of lymphocytesT cell nicheT cell homeostasisWhite blood cellsT cell apoptosisGraft rejectionAutoimmune disordersImmune cellsImmunological memoryLong-term protectionT cellsT lymphocytesImmune reactionsAntigen specificityInfectious agentsLymphocytesBlood cellsCell apoptosisMolecular pathwaysCell death mechanismsMature T cell homeostasisCell homeostasisCell deathDeath mechanisms
2012
A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers
LaBelle JL, Katz SG, Bird GH, Gavathiotis E, Stewart ML, Lawrence C, Fisher JK, Godes M, Pitter K, Kung AL, Walensky LD. A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. Journal Of Clinical Investigation 2012, 122: 2018-2031. PMID: 22622039, PMCID: PMC3366394, DOI: 10.1172/jci46231.Peer-Reviewed Original ResearchConceptsBcl-2 family proteinsCell deathFamily proteinsPro-apoptotic Bcl-2 family proteinsBcl-2 protein familyBcl-2-interacting mediatorBcl-2 family pathwayHydrocarbon-stapled peptidesCell death mechanismsCancer cellsCellular lifeHematologic cancer cellsProtein familyDeath domainBH3 helixBim BH3Bim peptidesDeath mechanismsApoptotic blockadesApoptotic resistanceFamily pathwaySurvival pathwaysAntiapoptotic proteinsProapoptotic activityHuman AML xenograft model
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