2015
The Transgenic RNAi Project at Harvard Medical School: Resources and Validation
Perkins LA, Holderbaum L, Tao R, Hu Y, Sopko R, McCall K, Yang-Zhou D, Flockhart I, Binari R, Shim HS, Miller A, Housden A, Foos M, Randkelv S, Kelley C, Namgyal P, Villalta C, Liu LP, Jiang X, Huan-Huan Q, Wang X, Fujiyama A, Toyoda A, Ayers K, Blum A, Czech B, Neumuller R, Yan D, Cavallaro A, Hibbard K, Hall D, Cooley L, Hannon GJ, Lehmann R, Parks A, Mohr SE, Ueda R, Kondo S, Ni JQ, Perrimon N. The Transgenic RNAi Project at Harvard Medical School: Resources and Validation. Genetics 2015, 201: 843-852. PMID: 26320097, PMCID: PMC4649654, DOI: 10.1534/genetics.115.180208.Peer-Reviewed Original Research
2003
Diversifying Neural Cells through Order of Birth and Asymmetry of Division
Zhong W. Diversifying Neural Cells through Order of Birth and Asymmetry of Division. Neuron 2003, 37: 11-14. PMID: 12526768, DOI: 10.1016/s0896-6273(02)01178-9.Peer-Reviewed Original ResearchConceptsAsymmetry of divisionCell fate diversificationCell fate determinationAsymmetric cell divisionMature nervous systemFate diversificationDrosophila genesFate determinationCell divisionCell typesProgenitor cellsNeural cellsDevelopmental neurobiologyNervous systemCommon setCellsDivisionGenesDiversityDiversificationKey questions
2001
The hedgehog pathway and basal cell carcinomas
Bale A, Yu K. The hedgehog pathway and basal cell carcinomas. Human Molecular Genetics 2001, 10: 757-762. PMID: 11257109, DOI: 10.1093/hmg/10.7.757.Peer-Reviewed Original ResearchConceptsGenetic studiesHereditary basal cell carcinomasDrosophila genesEmbryonic patterningDevelopmental genesDrosophila melanogasterCell fateHuman homologFruit flyHuman congenital anomaliesBiochemical pathwaysRational medical therapyDevelopmental pathwaysHedgehog pathwayGenesCell growthTumor formationPathwayGorlin syndromeBasal cell carcinomaMutationsHereditary diseaseBirth defectsDrosophilaMelanogaster
1999
A Novel Sulfonylurea Receptor Family Member Expressed in the Embryonic Drosophila Dorsal Vessel and Tracheal System*
Nasonkin I, Alikasifoglu A, Ambrose C, Cahill P, Cheng M, Sarniak A, Egan M, Thomas P. A Novel Sulfonylurea Receptor Family Member Expressed in the Embryonic Drosophila Dorsal Vessel and Tracheal System*. Journal Of Biological Chemistry 1999, 274: 29420-29425. PMID: 10506204, DOI: 10.1074/jbc.274.41.29420.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsATP-Binding Cassette TransportersCloning, MolecularDrosophilaDrosophila ProteinsGene Expression Regulation, DevelopmentalGlyburideHumansIn Situ HybridizationMolecular Sequence DataOocytesPatch-Clamp TechniquesPhylogenyPotassium ChannelsPotassium Channels, Inwardly RectifyingReceptors, DrugRNA, MessengerSulfonylurea ReceptorsXenopus laevisConceptsDrosophila embryogenesisPotassium channel activityTracheal systemNovel Drosophila geneDrosophila dorsal vesselDorsal vesselABC transporter familyChannel activityReceptor family membersDrosophila genesGene duplicationPotassium channelsDrosophila systemTransporter familyGenetic approachesATP-sensitive potassium channel activityGenesFunctional studiesSulfonylurea receptorKir6.2 subunitEmbryogenesisATP-sensitive potassium channelsSURxSubunitsDistinctive sequence
1997
Molecular basis of the nevoid basal cell carcinoma syndrome
Wicking C, Bale A. Molecular basis of the nevoid basal cell carcinoma syndrome. Current Opinion In Pediatrics 1997, 9: 630-635. PMID: 9425597, DOI: 10.1097/00008480-199712000-00013.Peer-Reviewed Original ResearchConceptsWidespread developmental defectsHereditary basal cell carcinomasDrosophila genesEmbryonic patterningCell fateEmbryonic developmentHuman homologueMolecular basisDevelopmental defectsTumor suppressorCancer predispositionGenesLoss of heterozygosityCell growthChromosome 9q22.3Basal cell carcinoma syndromeNevoid basal cell carcinoma syndromeMutationsAutosomal dominant disorderBirth defectsDrosophilaDominant disorderCarcinoma syndromeOrganogenesisHomologuesDevelopmental Genes and Cancer: Role of Patched in Basal Cell Carcinoma of the Skin
Gailani M, Bale A. Developmental Genes and Cancer: Role of Patched in Basal Cell Carcinoma of the Skin. Journal Of The National Cancer Institute 1997, 89: 1103-1109. PMID: 9262247, DOI: 10.1093/jnci/89.15.1103.Peer-Reviewed Original ResearchConceptsHereditary basal cell carcinomasDrosophila genesEmbryonic patterningDevelopmental genesCell fateEmbryonic developmentHuman homologueSporadic basal cell carcinomasBiochemical pathwaysDevelopmental defectsRational medical therapyTumor suppressorGenetic studiesGenesLoss of heterozygosityCell growthChromosome 9q22.3Rare genetic disorderNevoid basal cell carcinoma syndromeBCC formationGenetic disordersBasal cell carcinomaPathwayDrosophilaPatchedEvolution of codon usage bias in Drosophila
Powell J, Moriyama E. Evolution of codon usage bias in Drosophila. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 7784-7790. PMID: 9223264, PMCID: PMC33704, DOI: 10.1073/pnas.94.15.7784.Peer-Reviewed Original ResearchConceptsCodon usage biasHigher codon usage biasUsage biasBiased genesMutation biasSynonymous sitesCodon biasAmino acidsLow codon usage biasDrosophila genesDNA evolutionEffect of recombinationSmall geneIndividual amino acidsLong genesSynonymous substitutionsTRNA poolPreferred codonsSynonymous polymorphismWobble positionDrosophilaSame nucleotideSelection hypothesisGenesLines of evidence
1993
The expression pattern of a Drosophila homolog to the mouse transcription factor HNF‐4 suggests a determinative role in gut formation.
Zhong W, Sladek F, Darnell J. The expression pattern of a Drosophila homolog to the mouse transcription factor HNF‐4 suggests a determinative role in gut formation. The EMBO Journal 1993, 12: 537-544. PMID: 8440243, PMCID: PMC413236, DOI: 10.1002/j.1460-2075.1993.tb05685.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsChromosome DeletionChromosome MappingDNA-Binding ProteinsDrosophilaGene ExpressionHepatocyte Nuclear Factor 4In Situ HybridizationIntestinal MucosaIntestinesKidneyLiverMiceMolecular Sequence DataPhenotypePhosphoproteinsRNA, MessengerSequence Homology, Amino AcidTranscription FactorsConceptsDNA-binding domainDrosophila genesGut formationHNF-4Binding domainIdentical DNA binding domainsZinc finger DNA-binding domainHepatocyte nuclear factor 3Transcription factor HNF-4Amino acidsGroup of genesLiver-specific gene expressionDrosophila homologDrosophila embryoDrosophila mutantsMouse genesHNF-3Cross-hybridizationLate embryogenesisChromosomal deletionsDrosophilaFat bodyGene expressionExpression patternsGenes
1992
Murine chromosomal location of four hepatocyte-enriched transcription factors: HNf-3α, HNF-3β, HNF-3γ, and HNF-4
Avraham K, Prezioso V, Chen W, Lai E, Sladek F, Zhong W, Darnell J, Jenkins N, Copeland N. Murine chromosomal location of four hepatocyte-enriched transcription factors: HNf-3α, HNF-3β, HNF-3γ, and HNF-4. Genomics 1992, 13: 264-268. PMID: 1612587, DOI: 10.1016/0888-7543(92)90241-j.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsChromosome MappingCrosses, GeneticDigestive SystemDNA-Binding ProteinsGene Expression RegulationGenetic MarkersHepatocyte Nuclear Factor 3-alphaHepatocyte Nuclear Factor 3-betaHepatocyte Nuclear Factor 3-gammaHepatocyte Nuclear Factor 4HumansMiceMice, Inbred C57BLMuridaeNuclear ProteinsPhosphoproteinsSpecies SpecificityTranscription FactorsConceptsHNF-3 familyHepatocyte-enriched transcription factorsHNF-3Transcription factorsHNF-4Positive-acting transcription factorsHepatocyte nuclear factor 3Analysis of restriction fragment length polymorphismsInterspecific backcross miceDNA-binding domainHNF-3 alphaRestriction fragment length polymorphismFragment length polymorphismDrosophila genesChromosomal locationMouse chromosomeRegulatory regionsHNF-3BBinding domainBackcross miceLength polymorphismEndoderm developmentGut cellsGenesBinding sites
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